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    vwf von Willebrand factor [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100492314, updated on 4-Nov-2024

    Summary

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    Official Symbol
    vwfprovided by Xenbase
    Official Full Name
    von Willebrand factorprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-921798
    See related
    Ensembl:ENSXETG00000023591 AllianceGenome:Xenbase:XB-GENE-921798
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    vwd; f8vwf
    Summary
    Predicted to be involved in blood coagulation and cell-substrate adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See vwf in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    54
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (18580749..18695652)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (8221689..8323346)

    Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100495624 Neighboring gene CD9 protein Neighboring gene anoctamin 2, calcium activated chloride channel Neighboring gene neurotrophin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and functional analysis of histidine residues essential for pH-dependent multimerization of von Willebrand factor. Dang LT, et al. J Biol Chem, 2011 Jul 22. PMID 21592973, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-substrate adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    von Willebrand factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256288.1 → NP_001243217.1  von Willebrand factor precursor

      See identical proteins and their annotated locations for NP_001243217.1

      Status: PROVISIONAL

      Source sequence(s)
      BK007996
      UniProtKB/TrEMBL
      F5XVC3, F6ZFC8
      Related
      ENSXETP00000050938.5, ENSXETT00000050938.5
      Conserved Domains (11) summary
      smart00041
      Location:2761 → 2839
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:349 → 385
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:854 → 1010
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:225 → 290
      C8; This domain contains 8 conserved cysteine residues
      cd01450
      Location:1270 → 1431
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam00092
      Location:1506 → 1666
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:34 → 177
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:651 → 706
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:579 → 647
      C8; C8 domain
      pfam16164
      Location:1196 → 1270
      VWA_N2; VWA N-terminal
      cl17735
      Location:2284 → 2343
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      18580749..18695652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031897751.1 → XP_031753611.1  von Willebrand factor isoform X1

      UniProtKB/TrEMBL
      A0A6I8Q175, F6ZFC8
      Related
      ENSXETP00000065960.2, ENSXETT00000101585.2
      Conserved Domains (11) summary
      smart00041
      Location:2795 → 2873
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:383 → 419
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:888 → 1044
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1085 → 1159
      C8; This domain contains 8 conserved cysteine residues
      cd01450
      Location:1304 → 1465
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl17735
      Location:2318 → 2377
      VWC; von Willebrand factor type C domain
      pfam00092
      Location:1540 → 1700
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:68 → 211
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:616 → 681
      C8; C8 domain
      pfam16164
      Location:1230 → 1304
      VWA_N2; VWA N-terminal
      cd19941
      Location:685 → 740
      TIL; trypsin inhibitor-like cysteine rich domain

    2. XM_031897752.1 → XP_031753612.1  von Willebrand factor isoform X2

      UniProtKB/TrEMBL
      A0A8J1J6W9, F6ZFC8
      Conserved Domains (11) summary
      smart00041
      Location:2761 → 2839
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00215
      Location:349 → 385
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:854 → 1010
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:1051 → 1125
      C8; This domain contains 8 conserved cysteine residues
      cd01450
      Location:1270 → 1431
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl17735
      Location:2284 → 2343
      VWC; von Willebrand factor type C domain
      pfam00092
      Location:1506 → 1666
      VWA; von Willebrand factor type A domain
      pfam00094
      Location:34 → 177
      VWD; von Willebrand factor type D domain
      pfam08742
      Location:582 → 647
      C8; C8 domain
      pfam16164
      Location:1196 → 1270
      VWA_N2; VWA N-terminal
      cd19941
      Location:651 → 706
      TIL; trypsin inhibitor-like cysteine rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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