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    APP amyloid beta precursor protein [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 100427716, updated on 17-Aug-2024

    Summary

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    Official Symbol
    APPprovided by VGNC
    Official Full Name
    amyloid beta precursor proteinprovided by VGNC
    Primary source
    VGNC:VGNC:80791
    Locus tag
    EGK_13348
    See related
    Ensembl:ENSMMUG00000014384
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    ABPP
    Orthologs
    human mouse all
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    Genomic context

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    See APP in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 3 NC_041756.1 (20490901..20777954)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 3 NC_027895.1 (20805477..21096395)

    Chromosome 3 - NC_041756.1Genomic Context describing neighboring genes Neighboring gene cysteine and tyrosine rich 1 Neighboring gene uncharacterized LOC106997295 Neighboring gene uncharacterized LOC106997296 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC114676831 Neighboring gene protein LLP homolog pseudogene Neighboring gene GA binding protein transcription factor subunit alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species. Song W, et al. Gene, 1998 Sep 14. PMID 9841227
    2. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Koo EH, et al. Neuron, 1990 Jan. PMID 2106906
    3. Molecular phylogenetics and the origins of placental mammals. Murphy WJ, et al. Nature, 2001 Feb 1. PMID 11214319
    4. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transition metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    amyloid-beta precursor protein; amyloid-beta A4 protein
    Names
    Alzheimer disease amyloid protein
    alzheimer disease amyloid A4 protein homolog
    amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
    amyloid beta A4 protein
    amyloid precursor protein
    amyloid-beta (A4) precursor protein
    beta-amyloid precursor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041756.1 Reference Mmul_10 Primary Assembly

      Range
      20490901..20777954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015133068.2 → XP_014988554.1  amyloid-beta A4 protein isoform X1

      UniProtKB/TrEMBL
      A0A8J8XRV9, F7CLP0, G7MNB1, H9Z172, I0FRG1
      Related
      ENSMMUP00000056416.2, ENSMMUT00000056454.2
      Conserved Domains (5) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 341
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam03494
      Location:677 → 713
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:716 → 766
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12925
      Location:366 → 548
      APP_E2; E2 domain of amyloid precursor protein

    2. XM_015133069.2 → XP_014988555.1  amyloid-beta A4 protein isoform X2

      UniProtKB/TrEMBL
      I0FRG1
      Conserved Domains (7) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam02177
      Location:31 → 131
      APP_N; Amyloid A4 N-terminal heparin-binding
      pfam03494
      Location:657 → 695
      Beta-APP; Beta-amyloid peptide (beta-APP)
      pfam10515
      Location:698 → 748
      APP_amyloid; beta-amyloid precursor protein C-terminus
      pfam12924
      Location:133 → 188
      APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
      pfam12925
      Location:366 → 548
      APP_E2; E2 domain of amyloid precursor protein

    3. XM_015133071.2 → XP_014988557.1  amyloid-beta A4 protein isoform X4

      UniProtKB/TrEMBL
      F7CLL9, I0FRG1
      Related
      ENSMMUP00000018897.3, ENSMMUT00000020188.4
      Conserved Domains (4) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:347 → 529
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:656 → 730
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

    4. XM_015133073.2 → XP_014988559.1  amyloid-beta A4 protein isoform X6

      UniProtKB/TrEMBL
      F7FJ79
      Conserved Domains (3) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam12925
      Location:291 → 473
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:600 → 674
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

    5. XM_015133070.2 → XP_014988556.1  amyloid-beta A4 protein isoform X3

      UniProtKB/TrEMBL
      I0FGN3, I0FRG1
      Related
      ENSMMUP00000018894.4, ENSMMUT00000020185.4
      Conserved Domains (4) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam00014
      Location:294 → 342
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
      pfam12925
      Location:347 → 529
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:674 → 748
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

    6. XM_015133072.2 → XP_014988558.1  amyloid-beta A4 protein isoform X5

      UniProtKB/TrEMBL
      F7CLM6, F7FJ79, I0FGN2
      Related
      ENSMMUP00000018896.4, ENSMMUT00000020187.4
      Conserved Domains (3) summary
      smart00006
      Location:24 → 188
      A4_EXTRA; amyloid A4
      pfam12925
      Location:291 → 473
      APP_E2; E2 domain of amyloid precursor protein
      cl41775
      Location:618 → 692
      JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29216.1 GenPept UniProtKB/Swiss-Prot:P29216

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