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    Nsun3 NOP2/Sun RNA methyltransferase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100360437, updated on 17-Aug-2024

    Summary

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    Symbol
    Nsun3provided by RGD
    Full Name
    NOP2/Sun RNA methyltransferase 3provided by RGD
    Primary source
    RGD:2322119
    See related
    EnsemblRapid:ENSRNOG00000070121 AllianceGenome:RGD:2322119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable tRNA (cytosine-5-)-methyltransferase activity. Predicted to be involved in regulation of mitochondrial translation and tRNA wobble base cytosine methylation. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 48. Orthologous to human NSUN3 (NOP2/Sun RNA methyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 30.1), Spleen (RPKM 24.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsun3 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50960187..51062366)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (37490832..37575607)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38535971..38590274)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478909 Neighboring gene programmed cell death 7, pseudogene 1 Neighboring gene NOP2/Sun RNA methyltransferase 3, pseudogene 1 Neighboring gene proline and serine rich coiled-coil 1, pseudogene 1 Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 127 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. Van Haute L, et al. Nat Commun, 2016 Jun 30. PMID 27356879, Free PMC Article
    2. NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met). Nakano S, et al. Nat Chem Biol, 2016 Jul. PMID 27214402
    3. NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. Haag S, et al. EMBO J, 2016 Oct 4. PMID 27497299, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA wobble base cytosine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
    Names
    NOL1/NOP2/Sun domain family member 3-like
    NOP2/Sun RNA methyltransferase family member 3
    NOP2/Sun domain family, member 3
    putative methyltransferase NSUN3
    NP_001414243.1
    XP_038944740.2
    XP_038944742.2
    XP_063126285.1
    XP_063126286.1
    XP_063126287.1
    XP_063126288.1
    XP_063126289.1
    XP_063126290.1
    XP_063126291.1
    XP_063126292.1
    XP_063126293.1
    XP_063126294.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427314.1 → NP_001414243.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I6AA97
      Related
      ENSRNOP00000088188.1, ENSRNOT00000096476.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50960187..51062366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270215.1 → XP_063126285.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X1

    2. XM_063270224.1 → XP_063126294.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X5

    3. XM_063270220.1 → XP_063126290.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X2

    4. XM_063270219.1 → XP_063126289.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X2

    5. XM_063270223.1 → XP_063126293.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X4

    6. XM_063270218.1 → XP_063126288.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X2

    7. XM_063270216.1 → XP_063126286.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X2

    8. XM_039088812.2 → XP_038944740.2  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8I6AS93
      Related
      ENSRNOP00000097670.1, ENSRNOT00000094250.2

    9. XM_063270217.1 → XP_063126287.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X2

    10. XM_039088814.2 → XP_038944742.2  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8I6AS93

    11. XM_063270221.1 → XP_063126291.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X4

    12. XM_063270222.1 → XP_063126292.1  tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial isoform X4

    RNA

    1. XR_010055930.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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