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    Lpcat2 lysophosphatidylcholine acyltransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100359680, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lpcat2provided by RGD
    Official Full Name
    lysophosphatidylcholine acyltransferase 2provided by RGD
    Primary source
    RGD:2325051
    See related
    EnsemblRapid:ENSRNOG00000016643 AllianceGenome:RGD:2325051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LPCAT-2; RGD1563994
    Summary
    Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; and 1-alkylglycerophosphocholine O-acetyltransferase activity. Predicted to be involved in membrane organization; phosphatidylcholine acyl-chain remodeling; and platelet activating factor biosynthetic process. Predicted to be located in Golgi stack; endoplasmic reticulum membrane; and lipid droplet. Predicted to be active in endoplasmic reticulum. Orthologous to human LPCAT2 (lysophosphatidylcholine acyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 61.3), Lung (RPKM 54.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lpcat2 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (30261369..30325715, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (14088389..14152742, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (15470177..15540704, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483613 Neighboring gene carboxylesterase 1A Neighboring gene solute carrier family 6 member 2 Neighboring gene calpain, small subunit 2 Neighboring gene matrix metallopeptidase 2 Neighboring gene uncharacterized LOC120098544

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers. Agarwal AK, et al. J Lipid Res, 2010 Aug. PMID 20363836, Free PMC Article
    2. Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury. Okubo M, et al. Mol Pain, 2012 Feb 2. PMID 22296727, Free PMC Article
    3. A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. Shindou H, et al. J Biol Chem, 2007 Mar 2. PMID 17182612
    4. Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine. Moessinger C, et al. J Biol Chem, 2011 Jun 17. PMID 21498505, Free PMC Article
    5. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data show the histological localization of PAF synthases and its receptor in the spinal cord following peripheral nerve injury.
      Title: Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-acylglycerophosphocholine O-acyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-alkylglycerophosphocholine O-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plasmalogen synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in membrane organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine acyl-chain remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet activating factor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet activating factor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet activating factor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidylcholine acyltransferase 2
    Names
    1-AGP acyltransferase 11
    1-AGPAT 11
    1-acylglycerol-3-phosphate O-acyltransferase 11
    1-acylglycerophosphocholine O-acyltransferase
    1-alkenylglycerophosphocholine O-acyltransferase
    1-alkylglycerophosphocholine O-acetyltransferase
    LPC acyltransferase 2
    acetyl-CoA:lyso-PAF acetyltransferase
    acetyl-CoA:lyso-platelet-activating factor acetyltransferase
    acyltransferase-like 1-A
    lysoPAFAT
    lysoPC acyltransferase 2
    NP_001258273.1
    XP_017456651.1
    XP_038953347.1
    XP_038953349.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271344.1 → NP_001258273.1  lysophosphatidylcholine acyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P0C1Q3
      UniProtKB/TrEMBL
      F1LN03
      Related
      ENSRNOP00000022359.5, ENSRNOT00000022359.9
      Conserved Domains (4) summary
      cd07991
      Location:116 → 327
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:103 → 254
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      cd00051
      Location:396 → 458
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:396 → 457
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      30261369..30325715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601162.3 → XP_017456651.1  lysophosphatidylcholine acyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      A6KD56

    2. XM_039097419.2 → XP_038953347.1  lysophosphatidylcholine acyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      A6KD56
      Conserved Domains (2) summary
      cd07991
      Location:61 → 272
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      cd00051
      Location:341 → 403
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. XM_039097421.2 → XP_038953349.1  lysophosphatidylcholine acyltransferase 2 isoform X3

      Conserved Domains (1) summary
      cd07991
      Location:116 → 327
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like

    RNA

    1. XR_010059956.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C1Q3.1 GenPept UniProtKB/Swiss-Prot:P0C1Q3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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