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    capn15 calpain 15 [ Danio rerio (zebrafish) ]

    Gene ID: 100330198, updated on 2-Nov-2024

    Summary

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    Official Symbol
    capn15provided by ZNC
    Official Full Name
    calpain 15provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-140106-70
    See related
    Ensembl:ENSDARG00000060600 AllianceGenome:ZFIN:ZDB-GENE-140106-70
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    solh
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity and metal ion binding activity. Predicted to act upstream of or within proteolysis. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See capn15 in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (39027353..39084491)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (39139516..39197099)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene noggin 2 Neighboring gene ankyrin repeat and fibronectin type III domain containing 1b Neighboring gene uncharacterized LOC137489278 Neighboring gene putative protein MSS51 homolog, mitochondrial Neighboring gene MSS51 mitochondrial translational activator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. KEPI plays a negative role in the repression that accompanies translational inhibition guided by the uORF element of human CHOP transcript during stress response. Lee HC, et al. Gene, 2022 Apr 5. PMID 35031423
    2. PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Ma Z, et al. Nature, 2019 Apr. PMID 30944473
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calpain-15
    Names
    small optic lobes homolog
    zmp:0000001110

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      39027353..39084491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002663847.7 → XP_002663893.2  calpain-15 isoform X2

      UniProtKB/TrEMBL
      A0A8M1RRB5, E7FAX5
      Related
      ENSDARP00000080000.4, ENSDART00000085565.6
      Conserved Domains (4) summary
      smart00547
      Location:47 → 71
      ZnF_RBZ; Zinc finger domain
      sd00025
      Location:167 → 186
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:384 → 403
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00648
      Location:526 → 829
      Peptidase_C2; Calpain family cysteine protease

    2. XM_021470406.2 → XP_021326081.1  calpain-15 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Q9Z9, A0A8M2BLF5
      Related
      ENSDARP00000151290.1, ENSDART00000185763.1
      Conserved Domains (4) summary
      smart00547
      Location:78 → 102
      ZnF_RBZ; Zinc finger domain
      cd00044
      Location:545 → 860
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      sd00025
      Location:80 → 99
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:415 → 434
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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