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    Cox16 cytochrome c oxidase assembly factor COX16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100302447, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cox16provided by RGD
    Official Full Name
    cytochrome c oxidase assembly factor COX16provided by RGD
    Primary source
    RGD:2311610
    See related
    EnsemblRapid:ENSRNOG00000047115 AllianceGenome:RGD:2311610
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 163.8), Adrenal (RPKM 101.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox16 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (106745424..106912523, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (101162231..101181277, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (105195387..105214366, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene SPARC related modular calcium binding 1 Neighboring gene uncharacterized LOC120103570 Neighboring gene uncharacterized LOC120103571 Neighboring gene uncharacterized LOC134479222 Neighboring gene solute carrier family 8 member A3 Neighboring gene a disintegrin and metallopeptidase domain 4-like 1 Neighboring gene uncharacterized LOC134479224 Neighboring gene a disintegrin and metalloprotease domain 4 Neighboring gene synaptojanin 2 binding protein Neighboring gene uncharacterized LOC103690066

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis. Aich A, et al. Elife, 2018 Jan 30. PMID 29381136, Free PMC Article
    2. COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2. Cerqua C, et al. Biochim Biophys Acta Bioenerg, 2018 Apr. PMID 29355485
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    COX16 cytochrome c oxidase assembly homolog
    Names
    COX16, cytochrome c oxidase assembly homolog
    cytochrome c oxidase assembly protein 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163153.1 → NP_001156625.1  COX16 cytochrome c oxidase assembly homolog

      See identical proteins and their annotated locations for NP_001156625.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JDM6
      Related
      ENSRNOP00000008954.5, ENSRNOT00000008954.7
      Conserved Domains (1) summary
      pfam14138
      Location:16 → 88
      COX16; Cytochrome c oxidase assembly protein COX16

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      106745424..106912523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261363.1 → XP_063117433.1  COX16 cytochrome c oxidase assembly homolog isoform X2

      UniProtKB/TrEMBL
      D3Z8B0

    2. XM_006240298.4 → XP_006240360.1  COX16 cytochrome c oxidase assembly homolog isoform X1

      Conserved Domains (1) summary
      pfam14138
      Location:16 → 68
      COX16; Cytochrome c oxidase assembly protein COX16
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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