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    f8 coagulation factor VIII, procoagulant component [ Danio rerio (zebrafish) ]

    Gene ID: 100302404, updated on 19-Jun-2024

    Summary

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    Official Symbol
    f8provided by ZNC
    Official Full Name
    coagulation factor VIII, procoagulant componentprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090629-2
    See related
    Ensembl:ENSDARG00000101385 AllianceGenome:ZFIN:ZDB-GENE-090629-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable copper ion binding activity and oxidoreductase activity. Acts upstream of or within blood coagulation; glial cell development; and retina development in camera-type eye. Human ortholog(s) of this gene implicated in factor VIII deficiency. Orthologous to human F8 (coagulation factor VIII). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (1007145..1042655)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (988910..1024391)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene arylsulfatase family, member Ia Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene uncharacterized LOC103912051 Neighboring gene solute carrier family 16 member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression analysis of coagulation factor VIII and plasminogen involved in immune response to GCRV, and immunity activity comparison of grass carp Ctenopharyngodon idella with different viral resistance. Wang H, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30557607
    2. Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. O'Connor MN, et al. Blood, 2009 May 7. PMID 19109564, Free PMC Article
    3. RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Raman R, et al. Sci Rep, 2020 Nov 19. PMID 33214638, Free PMC Article
    4. Genetic control of cellular morphogenesis in Müller glia. Charlton-Perkins M, et al. Glia, 2019 Jul. PMID 30924555, Free PMC Article
    5. NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway. Hu YW, et al. Sci Rep, 2017 Jun 7. PMID 28592872, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coagulation factor VIII

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      1007145..1042655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307649.3 → XP_009305924.1  coagulation factor VIII

      UniProtKB/TrEMBL
      A0A8M3BEX0
      Related
      ENSDARP00000130264.2, ENSDART00000172676.3
      Conserved Domains (3) summary
      smart00231
      Location:1507 → 1662
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:1511 → 1661
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl19115
      Location:1013 → 1193
      Cupredoxin; Cupredoxin superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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