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    capn15 calpain 15 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100127702, updated on 4-Nov-2024

    Summary

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    Official Symbol
    capn15provided by Xenbase
    Official Full Name
    calpain 15provided by Xenbase
    Primary source
    Xenbase:XB-GENE-5926484
    See related
    Ensembl:ENSXETG00000010331 AllianceGenome:Xenbase:XB-GENE-5926484
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    solh
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity and metal ion binding activity. Predicted to act upstream of or within proteolysis. Orthologous to human CAPN15 (calpain 15). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See capn15 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 9 NC_030685.2 (21139168..21170439)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 9 NC_030685.1 (15300635..15313659)

    Chromosome 9 - NC_030685.2Genomic Context describing neighboring genes Neighboring gene 2,4-dienoyl-CoA reductase 2 Neighboring gene RAB11 family interacting protein 3 (class II) Neighboring gene uncharacterized LOC105948350 Neighboring gene proline rich 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calpain-15
    Names
    small optic lobes homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113040.1 → NP_001106511.1  calpain-15

      See identical proteins and their annotated locations for NP_001106511.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154716
      UniProtKB/TrEMBL
      A0A803JJU9, A8WGH7
      Related
      ENSXETP00000108228.1, ENSXETT00000108949.1
      Conserved Domains (4) summary
      sd00025
      Location:10 → 29
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:255 → 274
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:121 → 146
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam00648
      Location:384 → 687
      Peptidase_C2; Calpain family cysteine protease

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      21139168..21170439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031892484.1 → XP_031748344.1  calpain-15 isoform X3

      UniProtKB/TrEMBL
      A0A6I8RE76, A0A803JJU9
      Related
      ENSXETP00000083277.2, ENSXETT00000082835.2
      Conserved Domains (4) summary
      PHA03247
      Location:83 → 333
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:10 → 29
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:255 → 274
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00648
      Location:393 → 696
      Peptidase_C2; Calpain family cysteine protease

    2. XM_031892482.1 → XP_031748342.1  calpain-15 isoform X1

      UniProtKB/TrEMBL
      A0A803JJU9, A0A8J1IRW8
      Conserved Domains (4) summary
      PHA03247
      Location:140 → 390
      PHA03247; large tegument protein UL36; Provisional
      sd00025
      Location:67 → 86
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:312 → 331
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00648
      Location:450 → 753
      Peptidase_C2; Calpain family cysteine protease

    3. XM_031892483.1 → XP_031748343.1  calpain-15 isoform X2

      UniProtKB/TrEMBL
      A0A803JJU9, F6TNB8
      Related
      ENSXETP00000022734.4, ENSXETT00000022734.5
      Conserved Domains (4) summary
      PHA03247
      Location:140 → 390
      PHA03247; large tegument protein UL36; Provisional
      cd00044
      Location:429 → 744
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      sd00025
      Location:67 → 86
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00029
      Location:312 → 331
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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