GAPDH glyceraldehyde-3-phosphate dehydrogenase [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: GAPDH
Gene description: glyceraldehyde-3-phosphate dehydrogenase
See related: Ensembl:ENSOCUG00000029891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	8	NC_067381.1 (79061268..79065349, complement)

Chromosome 8 - NC_067381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067381.1 Chromosome 8 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

has been shown that the stage of aggregate growth follows the first-order kinetics and the experimentally measured rate constant of the first order corresponds to heat-induced structural reorganization of UV-irradiated GAPDH containing concealed damage.
Title: Kinetic regime of aggregation of UV-irradiated glyceraldehyde-3-phosphate dehydrogenase from rabbit skeletal muscle.
Low micromolar levels of 3,4-dihydroxyphenylacetaldehyde caused extensive GAPDH aggregation and irreversibly inhibited enzyme activity.
Title: Inactivation of glyceraldehyde-3-phosphate dehydrogenase by the dopamine metabolite, 3,4-dihydroxyphenylacetaldehyde.
The level of GAPDH-AP DNA adduct formation depends on oxidation of the protein SH-groups; disulfide bond reduction in GAPDH leads to the loss of its ability to form the adducts with AP DNA
Title: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) interacts with apurinic/apyrimidinic sites in DNA.
The strength, selectivity, reversibility, and redox sensitivity of heme binding to GAPDH are consistent with it performing heme sensing or heme chaperone-like functions in cells.
Title: Heme binding properties of glyceraldehyde-3-phosphate dehydrogenase.
Purified UCH-L1 and GAPDH were nitrated in vitro with peroxynitrite and the presence of nitrated proteins was confirmed by anti-3-nitrotyrosine Western blots.Subsequent validation with synthetic peptides was conducted for selected nitropeptides.
Title: Identification of tyrosine nitration in UCH-L1 and GAPDH.
dissociation of alpha-crystallin and GAPDH
Title: Role of thermoinduced dissociation in interaction between alpha-crystallin as an oligomeric chaperone and glyceraldehyde-3-phosphate dehydrogenase as an oligomeric protein substrate.
results strongly suggest that Tyr311 and Tyr317 nitration prohibits NAD(+) binding, leading to the loss of catalytic activity of GAPDH.
Title: Mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by tyrosine nitration.
In the presence of alpha-crystallin or GroEL the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.
Title: Comparative analysis of the effects of alpha-crystallin and GroEL on the kinetics of thermal aggregation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase.
FKBP36 diminishes GAPDH activity by direct interaction and down-regulation of GAPDH
Title: FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor.
The interactions described herein between the beta subunit of PhK and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.
Title: The regulatory beta subunit of phosphorylase kinase interacts with glyceraldehyde-3-phosphate dehydrogenase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC122612P1 (e-PCR)
- UniSTS:270402

Gapdh (e-PCR), detects polymorphism
- UniSTS:496721

PMC109593P1 (e-PCR)
- UniSTS:270172

PMC303337P3 (e-PCR)
- UniSTS:272495

PMC141140P1 (e-PCR)
- UniSTS:270988

PMC112637P1 (e-PCR)
- UniSTS:270236

MARC_2058-2059:966880818:1 (e-PCR)
- UniSTS:268455

PMC113197P2 (e-PCR)
- UniSTS:270250

PMC21468P1 (e-PCR)
- UniSTS:272060

PMC21573P1 (e-PCR)
- UniSTS:272061

PMC266773P1 (e-PCR)
- UniSTS:272348

PMC115884P2 (e-PCR)
- UniSTS:270303

PMC26839P1 (e-PCR)
- UniSTS:272355

PMC101742P3 (e-PCR)
- UniSTS:270065

PMC97327P1 (e-PCR)
- UniSTS:273649

PMC98059P1 (e-PCR)
- UniSTS:273662

PMC150799P1 (e-PCR)
- UniSTS:271103

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables NADP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glyceraldehyde-3-phosphate dehydrogenase

Names: peptidyl-cysteine S-nitrosylase GAPDH

NP_001075722.1

EC 1.2.1.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082253.1 → NP_001075722.1 glyceraldehyde-3-phosphate dehydrogenase

See identical proteins and their annotated locations for NP_001075722.1

Status: PROVISIONAL

Source sequence(s)

L23961

UniProtKB/Swiss-Prot

P46406, Q4AC92

Related

ENSOCUP00000044112.1, ENSOCUT00000036324.1

Conserved Domains (3) summary

COG0057
Location:1 → 333

GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]

pfam00044
Location:2 → 150

Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

pfam02800
Location:155 → 312

Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain