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    PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial [ Ovis aries (sheep) ]

    Gene ID: 101120669, updated on 8-Mar-2024

    Summary

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    Gene symbol
    PCK2
    Gene description
    phosphoenolpyruvate carboxykinase 2, mitochondrial
    See related
    EnsemblRapid:ENSOARG00020011047
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    See PCK2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 7 NC_056060.1 (20852807..20861068, complement)

    Chromosome 7 - NC_056060.1Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 9 Neighboring gene proteasome activator subunit 1 Neighboring gene fat storage inducing transmembrane protein 1 Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene neural retina leucine zipper Neighboring gene copine 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056060.1 Chromosome 7 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation. Gentili S, et al. Biol Reprod, 2009 Jun. PMID 19208549, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hepatic expression of phosphoenolpyruvate carboxykinase 2 increased in placental restriction-hypoxic reduced liver growth.
      Title: Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphoenolpyruvate carboxykinase (GTP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glycerol biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in hepatocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in propionate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to starvation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxykinase [GTP], mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056060.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      20852807..20861068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015096868.3 → XP_014952354.1  phosphoenolpyruvate carboxykinase [GTP], mitochondrial

      UniProtKB/TrEMBL
      A0A6P3YMI7, W5QD66
      Related
      ENSOARP00020013946.2, ENSOART00020016887.2
      Conserved Domains (1) summary
      cd00819
      Location:44 → 633
      PEPCK_GTP; Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and ...
    Nucleotide Protein Strain
    Heading Accession and Version

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