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    E7 E7 protein [ human papillomavirus 18 ]

    Gene ID: 1489089, updated on 18-Aug-2023

    Summary

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    Gene symbol
    E7
    Gene description
    E7 protein
    Locus tag
    HpV18gp2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    human papillomavirus 18
    Lineage
    Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus
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    Genomic context

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    Sequence:
    NC_001357.1 (590..907)

    NC_001357.1Genomic Context describing neighboring genes Neighboring gene E6 protein Neighboring gene E1 Neighboring gene E2 protein Neighboring gene E4 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001357.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation. Lou M, et al. J Med Virol, 2023 Jan. PMID 36377393, Free PMC Article
    2. Human papillomavirus (HPV) E7 induces prolonged G2 following S phase reentry in differentiated human keratinocytes. Banerjee NS, et al. J Biol Chem, 2011 Apr 29. PMID 21321122, Free PMC Article
    3. A C-terminal hydrophobic, solvent-protected core and a flexible N-terminus are potentially required for human papillomavirus 18 E7 protein functionality. Liu S, et al. Biochimie, 2010 Jul. PMID 20211680
    4. In vitro antigen-specific cytotoxic T cell response against esophageal carcinoma cells induced by HPV18E7-transfected dendritic cells. Wu L, et al. Histol Histopathol, 2010 Feb. PMID 20017106
    5. Molecular mechanisms of hyperplasia induction by human papillomavirus E7. Ueno T, et al. Oncogene, 2006 Jul 13. PMID 16501608

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
      Title: DNA virus oncoprotein HPV18 E7 selectively antagonizes cGAS-STING-triggered innate immune activation.
    2. Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18.
      Title: Nanog, in Cooperation with AP1, Increases the Expression of E6/E7 Oncogenes from HPV Types 16/18.
    3. CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18.
      Title: CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18.
    4. HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cells.
      Title: HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cells.
    5. Alternative splicing of E6E7 transcripts showed E6*I as the most frequent isoform for both viral types, followed by E6*II and E6/E7 (unspliced) transcripts in HPV16+, and by E6/E7 in HPV18+ tumors.
      Title: Characterization of HPV integration, viral gene expression and E6E7 alternative transcripts by RNA-Seq: A descriptive study in invasive cervical cancer.
    6. Results indicate the significance and therapeutic potential of the intermolecular interaction between HPV18 E7 and host protein tyrosine phosphatase non-receptor type 14 (PTPN14) in HPV-mediated cell transformation and tumorigenesis.
      Title: Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus.
    7. These data suggest that HPV18 modulates its production ratio of E6 and E7 proteins by alternative selection of the two mapped branch sites for the E6*I splicing, which could be beneficial in its productive or oncogenic infection according to the host cell environment.
      Title: HPV18 Utilizes Two Alternative Branch Sites for E6*I Splicing to Produce E7 Protein.
    8. Findings indicate O-linked N-acetylglucosamine transferase (OGT) as a cellular factor involved in human papillomaviruses type 16/18 E6 and E7 expressions and cervical cancer tumorigenesis, suggesting that targeting OGT in cervical cancer may have potential therapeutic benefit.
      Title: O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes.
    9. HPV18 E7 inhibited the binding of CENP-C to alpha-satellite DNAs.
      Title: The human papillomavirus18 E7 protein inhibits CENP-C binding to α-satellite DNA.
    10. HPV18 E7 mRNA expression levels were not significantly altered by 10 microg/ml bee-venom-treatment in HeLa cells.
      Title: Honeybee venom possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer cell line.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    E7 protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001357.1 Reference assembly

      Range
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040311.1 E7 protein [human papillomavirus 18]

      See identical proteins and their annotated locations for NP_040311.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P06788
      UniProtKB/TrEMBL
      A0A1X9ZDV5, A0A1X9ZDX4, A0A291PNZ9, A0A5J6SGX5, A0A6F8Z817, A0A6F8Z8C7, A0A6J4B3S8, A9XFF1, D3ITV6, Q76Z96, Q9QNP7, T2A6S6
      Conserved Domains (1) summary
      cl02891
      Location:1 → 104
      E7; E7 protein, Early protein
    Nucleotide Protein
    Heading Accession and Version

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