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    Spata1 spermatogenesis associated 1 [ Mus musculus (house mouse) ]

    Gene ID: 70951, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Spata1provided by MGI
    Official Full Name
    spermatogenesis associated 1provided by MGI
    Primary source
    MGI:MGI:1918201
    See related
    Ensembl:ENSMUSG00000028188 AllianceGenome:MGI:1918201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SP-2; 4921536I21Rik
    Summary
    Located in acrosomal vesicle. Orthologous to human SPATA1 (spermatogenesis associated 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 21.9), CNS E11.5 (RPKM 1.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Spata1 in Genome Data Viewer
    Location:
    3 H2; 3 71.3 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (146162955..146205548, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (146457202..146499793, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22078 Neighboring gene SSX family member 2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E9230 Neighboring gene chitobiase Neighboring gene STARR-positive B cell enhancer ABC_E6144 Neighboring gene G protein subunit gamma 5 Neighboring gene STARR-positive B cell enhancer ABC_E11229 Neighboring gene ribosome production factor 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein. Zhang L, et al. Dev Dyn, 2020 Apr. PMID 31816150, Free PMC Article
    2. Disruption of G-protein γ5 subtype causes embryonic lethality in mice. Moon AM, et al. PLoS One, 2014. PMID 24599258, Free PMC Article
    3. Centimorgan-range one-step mapping of fertility traits using interspecific recombinant congenic mice. L'Hôte D, et al. Genetics, 2007 Jul. PMID 17483418, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein.
      Title: Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    NOT located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spermatogenesis-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316756.2 → NP_001303685.1  spermatogenesis-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC124987, AC141632
      Consensus CDS
      CCDS38666.1
      UniProtKB/Swiss-Prot
      B9EI96, Q7TPN4, Q9D5R4
      Related
      ENSMUSP00000142800.2, ENSMUST00000197980.5
      Conserved Domains (1) summary
      pfam15743
      Location:279 → 428
      SPATA1_C; Spermatogenesis-associated C-terminus

    2. NM_001370604.1 → NP_001357533.1  spermatogenesis-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124987, AC141632
      Conserved Domains (1) summary
      pfam15743
      Location:276 → 386
      SPATA1_C; Spermatogenesis-associated C-terminus

    3. NM_027617.3 → NP_081893.1  spermatogenesis-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_081893.1

      Status: VALIDATED

      Source sequence(s)
      AC124987, AC141632
      Consensus CDS
      CCDS38666.1
      UniProtKB/Swiss-Prot
      B9EI96, Q7TPN4, Q9D5R4
      Related
      ENSMUSP00000029839.5, ENSMUST00000029839.11
      Conserved Domains (1) summary
      pfam15743
      Location:279 → 428
      SPATA1_C; Spermatogenesis-associated C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      146162955..146205548 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163322.1 → XP_036019215.1  spermatogenesis-associated protein 1 isoform X5

      Conserved Domains (1) summary
      pfam15743
      Location:233 → 365
      SPATA1_C; Spermatogenesis-associated C-terminus

    2. XM_036163320.1 → XP_036019213.1  spermatogenesis-associated protein 1 isoform X3

      Conserved Domains (1) summary
      pfam15743
      Location:259 → 407
      SPATA1_C; Spermatogenesis-associated C-terminus

    3. XM_036163323.1 → XP_036019216.1  spermatogenesis-associated protein 1 isoform X6

      Conserved Domains (1) summary
      pfam15743
      Location:276 → 353
      SPATA1_C; Spermatogenesis-associated C-terminus

    4. XM_036163321.1 → XP_036019214.1  spermatogenesis-associated protein 1 isoform X4

      Conserved Domains (1) summary
      pfam15743
      Location:280 → 395
      SPATA1_C; Spermatogenesis-associated C-terminus

    5. XM_036163317.1 → XP_036019210.1  spermatogenesis-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15743
      Location:280 → 408
      SPATA1_C; Spermatogenesis-associated C-terminus

    6. XM_036163318.1 → XP_036019211.1  spermatogenesis-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15743
      Location:280 → 408
      SPATA1_C; Spermatogenesis-associated C-terminus

    7. XM_036163319.1 → XP_036019212.1  spermatogenesis-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam15743
      Location:280 → 408
      SPATA1_C; Spermatogenesis-associated C-terminus

    8. XM_006502090.5 → XP_006502153.1  spermatogenesis-associated protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006502153.1

      UniProtKB/Swiss-Prot
      B9EI96, Q7TPN4, Q9D5R4
      Conserved Domains (1) summary
      pfam15743
      Location:279 → 428
      SPATA1_C; Spermatogenesis-associated C-terminus

    9. XM_036163324.1 → XP_036019217.1  spermatogenesis-associated protein 1 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D5R4.1 GenPept UniProtKB/Swiss-Prot:Q9D5R4

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