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    Mrpl17 mitochondrial ribosomal protein L17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171061, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrpl17provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L17provided by RGD
    Primary source
    RGD:70943
    See related
    EnsemblRapid:ENSRNOG00000019497 AllianceGenome:RGD:70943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    L17mt; MRP-L17
    Summary
    Predicted to enable protein domain specific binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL17 (mitochondrial ribosomal protein L17). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 560.0), Adrenal (RPKM 413.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl17 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (169574010..169575699, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (160162181..160163870, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (170652293..170653982, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tripeptidyl peptidase 1 Neighboring gene dachsous cadherin-related 1 Neighboring gene uncharacterized LOC134483767 Neighboring gene GTPase, very large interferon inducible 1 Neighboring gene egl-9 family hypoxia-inducible factor 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins. Tchernev VT, et al. Mol Med, 2002 Jan. PMID 11984006, Free PMC Article
    2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein bL17m
    Names
    39S ribosomal protein L17, mitochondrial
    Na++/Ca++ exchanger-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313842.1 → NP_001300771.1  large ribosomal subunit protein bL17m isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      FM050943, FM126647, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6PDW6, Q9EPG8
      UniProtKB/TrEMBL
      A0A8I6A9S2, A6I7N9
      Conserved Domains (1) summary
      pfam01196
      Location:28 → 126
      Ribosomal_L17; Ribosomal protein L17

    2. NM_001313843.1 → NP_001300772.1  large ribosomal subunit protein bL17m isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      FM050943, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I7N7
      Conserved Domains (1) summary
      pfam01196
      Location:28 → 99
      Ribosomal_L17; Ribosomal protein L17

    3. NM_133539.2 → NP_598223.2  large ribosomal subunit protein bL17m isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) retains an intron in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      FM050864, FM099507, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q6PDW6, Q9EPG8
      UniProtKB/TrEMBL
      A0A8I6A9S2, A6I7N9
      Related
      ENSRNOP00000090550.1, ENSRNOT00000102735.2
      Conserved Domains (1) summary
      pfam01196
      Location:28 → 126
      Ribosomal_L17; Ribosomal protein L17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      169574010..169575699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDW6.1 GenPept UniProtKB/Swiss-Prot:Q6PDW6

    Gene LinkOut

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