Fbxo17 F-box protein 17 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo17provided by MGI
Official Full Name: F-box protein 17provided by MGI
Primary source: MGI:MGI:1354707
See related: Ensembl:ENSMUSG00000030598 AllianceGenome:MGI:1354707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbg4; Fbx17; Fbxo26
Summary: Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and glycoprotein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO17 (F-box protein 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 11.3), ovary adult (RPKM 6.0) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 16.9 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (28416176..28437570)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (28716749..28738145)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identified FBXO17 as an F-box protein subunit that recognizes and mediates GSK3beta polyubiquitination.
Title: SCF(FBXO17) E3 ligase modulates inflammation by regulating proteasomal degradation of glycogen synthase kinase-3β in lung epithelia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box only protein 17

Names: F-box only protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310687.1 → NP_001297616.1 F-box only protein 17 isoform 2

See identical proteins and their annotated locations for NP_001297616.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC109162, AC171210

Consensus CDS

CCDS80688.1

UniProtKB/Swiss-Prot

Q9QZM8

Related

ENSMUSP00000103914.3, ENSMUST00000108279.9

Conserved Domains (2) summary

pfam04300
Location:109 → 239

FBA; F-box associated region

pfam12937
Location:18 → 59

F-box-like; F-box-like
NM_015796.2 → NP_056611.2 F-box only protein 17 isoform 1

See identical proteins and their annotated locations for NP_056611.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC171210, AF176532, BY145793

Consensus CDS

CCDS39863.2

UniProtKB/Swiss-Prot

Q9QZM8

UniProtKB/TrEMBL

Q3V064

Related

ENSMUSP00000032818.7, ENSMUST00000032818.13

Conserved Domains (2) summary

pfam04300
Location:109 → 281

FBA; F-box associated region

pfam12937
Location:18 → 59

F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

28416176..28437570

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006540169.4 → XP_006540232.1 F-box only protein 17 isoform X1

Conserved Domains (2) summary

pfam04300
Location:108 → 239

FBA; F-box associated region

pfam12937
Location:18 → 59

F-box-like