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    tbce tubulin folding cofactor E [ Danio rerio (zebrafish) ]

    Gene ID: 664760, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tbceprovided by ZNC
    Official Full Name
    tubulin folding cofactor Eprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-051030-120
    See related
    Ensembl:ENSDARG00000099921 AllianceGenome:ZFIN:ZDB-GENE-051030-120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:123075
    Summary
    Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Kenny-Caffey syndrome type 1; hypoparathyroidism; and hypoparathyroidism-retardation-dysmorphism syndrome. Orthologous to human TBCE (tubulin folding cofactor E). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See tbce in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (44606545..44622250, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (44344513..44360218, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 137Bb Neighboring gene nidogen 1b Neighboring gene RNA binding motif protein 34 Neighboring gene translocase of outer mitochondrial membrane 20b Neighboring gene uncharacterized LOC137496742 Neighboring gene interferon regulatory factor 2 binding protein 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC123075

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-chaperonin tubulin folding pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tubulin-specific chaperone E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039989.2 → NP_001035078.2  tubulin-specific chaperone E

      See identical proteins and their annotated locations for NP_001035078.2

      Status: VALIDATED

      Source sequence(s)
      BC085669, BX569779
      UniProtKB/Swiss-Prot
      Q5U378
      Related
      ENSDARP00000132970.1, ENSDART00000171837.2
      Conserved Domains (4) summary
      smart01052
      Location:7 → 71
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd00116
      Location:144 → 338
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:148 → 173
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:224 → 282
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      44606545..44622250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155925.5 → XP_005155982.1  tubulin-specific chaperone E isoform X1

      See identical proteins and their annotated locations for XP_005155982.1

      UniProtKB/Swiss-Prot
      Q5U378
      Conserved Domains (4) summary
      smart01052
      Location:7 → 71
      CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
      cd00116
      Location:144 → 338
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:148 → 173
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:224 → 282
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U378.2 GenPept UniProtKB/Swiss-Prot:Q5U378

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