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    Gapdh1 Glyceraldehyde 3 phosphate dehydrogenase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35728, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gapdh1provided by FlyBase
    Official Full Name
    Glyceraldehyde 3 phosphate dehydrogenase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0001091
    Locus tag
    Dmel_CG12055
    See related
    AllianceGenome:FB:FBgn0001091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH12586; CG12055; Dmel\CG12055; dmGAPDH; GA3PDH; GADPH; Gadph1; GAP; Gapd; gapdh; Gapdh; GAPDH; GAPDH I; gapdh-1; Gapdh-1; GAPDH-1; gapdh1; GAPDH1; Gapdh43E; GAPDHI; gh12586
    Summary
    Enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity. Involved in glyceraldehyde-3-phosphate metabolic process and glycolytic process. Located in M band and Z disc. Is expressed in several structures, including adult head; adult heart; germline cell; mesoderm; and muscle cell. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human GAPDH (glyceraldehyde-3-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Gapdh1 in Genome Data Viewer
    Location:
    43E17-43E17; 2-57 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7791901..7793380, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3679406..3680885, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA polymerase zeta subunit 1 Neighboring gene Nop17 like Neighboring gene saxophone

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference. Caplen NJ, et al. Gene, 2000 Jul 11. PMID 10903441
    2. Vesicular glycolysis provides on-board energy for fast axonal transport. Zala D, et al. Cell, 2013 Jan 31. PMID 23374344
    3. Glyceraldehyde-3-phosphate dehydrogenase from Drosophila melanogaster. Identification of two isozymic forms encoded by separate genes. Sullivan DT, et al. J Biol Chem, 1985 Apr 10. PMID 2984203
    4. Structure of two unlinked Drosophila melanogaster glyceraldehyde-3-phosphate dehydrogenase genes. Tso JY, et al. J Biol Chem, 1985 Jul 5. PMID 2989282
    5. Differential regulation of the two glyceraldehyde-3-phosphate dehydrogenase genes during Drosophila development. Sun XH, et al. Mol Cell Biol, 1988 Dec. PMID 3149711, Free PMC Article

    See all (149) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-cysteine S-nitrosylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in gluconeogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glyceraldehyde-3-phosphate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glyceraldehyde 3 phosphate dehydrogenase 1
    Names
    CG12055-PA
    CG12055-PB
    G3-P dehydrogenase
    GAPDH1
    Gapdh1-PA
    Gapdh1-PB
    Glyceraldehyde-3-phosphate dehydrogenase1
    dehydrogenase
    glyceraldehyde 3 phosphate dehydrogenase
    glyceraldehyde 3 phosphate dehydrogenase1
    glyceraldehyde-3-phosphate
    glyceraldehyde-3-phosphate dehydrogenase
    NP_001033936.1
    NP_525108.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7791901..7793380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080369.3 → NP_525108.2  glyceraldehyde 3 phosphate dehydrogenase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525108.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ75, A5XCT3, A5XCT7, P07486, Q8SXG8, Q9V318
      Related
      FBpp0087977
      Conserved Domains (3) summary
      COG0057
      Location:1 → 332
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam00044
      Location:3 → 149
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:154 → 311
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

    2. NM_001038847.2 → NP_001033936.1  glyceraldehyde 3 phosphate dehydrogenase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ75, A5XCT3, A5XCT7, P07486, Q8SXG8, Q9V318
      Conserved Domains (3) summary
      COG0057
      Location:1 → 332
      GapA; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]
      pfam00044
      Location:3 → 149
      Gp_dh_N; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain
      pfam02800
      Location:154 → 311
      Gp_dh_C; Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07486.2 P07486

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