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    Gpr174 G protein-coupled receptor 174 [ Mus musculus (house mouse) ]

    Gene ID: 213439, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gpr174provided by MGI
    Official Full Name
    G protein-coupled receptor 174provided by MGI
    Primary source
    MGI:MGI:2685222
    See related
    Ensembl:ENSMUSG00000073008 AllianceGenome:MGI:2685222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm376; Lypsr3
    Summary
    Enables bioactive lipid receptor activity. Acts upstream of or within T cell homeostasis. Predicted to be located in centriolar satellite and intracellular membrane-bounded organelle. Predicted to be active in plasma membrane. Orthologous to human GPR174 (G protein-coupled receptor 174). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Gpr174 in Genome Data Viewer
    Location:
    X D; X 47.48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (106299484..106340377)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (107255878..107296771)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11054 Neighboring gene STARR-positive B cell enhancer ABC_E11686 Neighboring gene purinergic receptor P2Y, G-protein coupled 10B Neighboring gene prohibitin pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chrX:104413022-104413322 Neighboring gene STARR-positive B cell enhancer ABC_E7704 Neighboring gene alpha-enolase pseudogene Neighboring gene STARR-seq mESC enhancer starr_47743 Neighboring gene glutamate dehydrogenase 1 pseudogene Neighboring gene ribosomal protein L7a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells. Wolf EW, et al. Proc Natl Acad Sci U S A, 2022 Jun 7. PMID 35639700, Free PMC Article
    2. GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling. Yue J, et al. Biomed Pharmacother, 2020 Feb. PMID 31918274
    3. The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice. Zhu M, et al. Int Immunopharmacol, 2020 Apr. PMID 31786099
    4. Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice. Qiu D, et al. Cell Death Dis, 2019 Mar 8. PMID 30850582, Free PMC Article
    5. GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression. Liu J, et al. Nat Commun, 2022 Dec 6. PMID 36473866, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression.
      Title: GPR174 knockdown enhances blood flow recovery in hindlimb ischemia mice model by upregulating AREG expression.
    2. GPR174 signals via Galphas to control a CD86-containing gene expression program in B cells.
      Title: GPR174 signals via Gαs to control a CD86-containing gene expression program in B cells.
    3. GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
      Title: GPR174 mRNA Acts as a Novel Prognostic Biomarker for Patients With Sepsis via Regulating the Inflammatory Response.
    4. The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice.
      Title: The increased marginal zone B cells attenuates early inflammatory responses during sepsis in Gpr174 deficient mice.
    5. GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling.
      Title: GPR174 suppression attenuates retinopathy in angiotensin II (Ang II)-treated mice by reducing inflammation via PI3K/AKT signaling.
    6. the findings suggested that GPR174 plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions.
      Title: Gpr174-deficient regulatory T cells decrease cytokine storm in septic mice.
    7. By identifying GPR174 as a receptor for CCL21 and demonstrating its sex-dependent control of B-cell positioning and participation in germinal centres, we have revealed a mechanism by which B-cell physiology is fine-tuned to impart sexual dimorphism to humoral immunity
      Title: A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity.
    8. Lysophosphatidyl serine acts via GPR174 and Galphas to suppress IL-2 production by activated T cells
      Title: Lysophosphatidylserine suppression of T-cell activation via GPR174 requires Gαs proteins.
    9. The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
      Title: The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bioactive lipid receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 174
    Names
    putative purinergic receptor FKSG79

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033251.5 → NP_001028423.1  probable G-protein coupled receptor 174

      See identical proteins and their annotated locations for NP_001028423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
      Source sequence(s)
      AK153611, AL663081
      Consensus CDS
      CCDS30348.1
      UniProtKB/Swiss-Prot
      Q3U507
      Related
      ENSMUSP00000112974.2, ENSMUST00000120971.8
      Conserved Domains (1) summary
      cd15152
      Location:20 → 303
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001177781.1 → NP_001171252.1  probable G-protein coupled receptor 174

      See identical proteins and their annotated locations for NP_001171252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
      Source sequence(s)
      AL663081
      Consensus CDS
      CCDS30348.1
      UniProtKB/Swiss-Prot
      Q3U507
      Related
      ENSMUSP00000098852.3, ENSMUST00000101294.9
      Conserved Domains (1) summary
      cd15152
      Location:20 → 303
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001177782.1 → NP_001171253.1  probable G-protein coupled receptor 174

      See identical proteins and their annotated locations for NP_001171253.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
      Source sequence(s)
      AL663081, BQ562837
      Consensus CDS
      CCDS30348.1
      UniProtKB/Swiss-Prot
      Q3U507
      Related
      ENSMUSP00000137372.2, ENSMUST00000178838.2
      Conserved Domains (1) summary
      cd15152
      Location:20 → 303
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_001358747.1 → NP_001345676.1  probable G-protein coupled receptor 174

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein. An upstream AUG is present that would result in a 13 aa N-terminal extension, but it has a weak Kozak signal and is absent in other mammals, whereas the annotated dAUG has a stronger Kozak signal and is well-conserved among mammals.
      Source sequence(s)
      AL663081
      Consensus CDS
      CCDS30348.1
      UniProtKB/Swiss-Prot
      Q3U507
      Related
      ENSMUSP00000113032.2, ENSMUST00000118820.8
      Conserved Domains (1) summary
      cd15152
      Location:20 → 303
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      106299484..106340377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318457.2 → XP_017173946.1  probable G-protein coupled receptor 174 isoform X1

      Conserved Domains (1) summary
      cd15152
      Location:33 → 316
      7tmA_GPR174-like; putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U507.1 GenPept UniProtKB/Swiss-Prot:Q3U507

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