Cdon cell adhesion associated, oncogene regulated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdonprovided by RGD
Official Full Name: cell adhesion associated, oncogene regulatedprovided by RGD
Primary source: RGD:708433
See related: EnsemblRapid:ENSRNOG00000011789 AllianceGenome:RGD:708433
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cdo
Summary: Involved in cell adhesion. Acts upstream of or within smoothened signaling pathway. Located in cell surface. Human ortholog(s) of this gene implicated in holoprosencephaly 11. Orthologous to human CDON (cell adhesion associated, oncogene regulated). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Muscle (RPKM 58.7), Lung (RPKM 50.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q21

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (42032921..42119451)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (33775123..33861635)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (36625757..36712091)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in embryonic body morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic retina morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in lens development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of small GTPase mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle satellite cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule-related/down-regulated by oncogenes

Names: Cdon homolog; immunoglobulin superfamily member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017358.3 → NP_059054.2 cell adhesion molecule-related/down-regulated by oncogenes precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

O35158

UniProtKB/TrEMBL

A6JYK5, G3V7K7

Conserved Domains (6) summary

smart00408
Location:236 → 294

IGc2; Immunoglobulin C-2 Type

cd00063
Location:718 → 808

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:588 → 663

fn3; Fibronectin type III domain

pfam07679
Location:405 → 517

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

42032921..42119451

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242791.5 → XP_006242853.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

Related

ENSRNOP00000016247.1, ENSRNOT00000016248.6

Conserved Domains (6) summary

smart00408
Location:236 → 294

IGc2; Immunoglobulin C-2 Type

cd00063
Location:718 → 808

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:588 → 663

fn3; Fibronectin type III domain

pfam07679
Location:405 → 517

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_006242793.5 → XP_006242855.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X2

UniProtKB/Swiss-Prot

O35158

UniProtKB/TrEMBL

A0A8I6A2E2

Related

ENSRNOP00000085481.1, ENSRNOT00000103041.2

Conserved Domains (5) summary

smart00408
Location:326 → 387

IGc2; Immunoglobulin C-2 Type

smart00410
Location:227 → 306

IG_like; Immunoglobulin like

cd00063
Location:600 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:313 → 397

I-set; Immunoglobulin I-set domain

cl11960
Location:33 → 113

Ig; Immunoglobulin domain
XM_006242792.5 → XP_006242854.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

See identical proteins and their annotated locations for XP_006242854.1

UniProtKB/Swiss-Prot

O35158

UniProtKB/TrEMBL

A6JYK5, G3V7K7

Conserved Domains (6) summary

smart00408
Location:236 → 294

IGc2; Immunoglobulin C-2 Type

cd00063
Location:718 → 808

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:588 → 663

fn3; Fibronectin type III domain

pfam07679
Location:405 → 517

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain
XM_063266036.1 → XP_063122106.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

UniProtKB/TrEMBL

A6JYK5, G3V7K7
XM_039082008.2 → XP_038937936.1 cell adhesion molecule-related/down-regulated by oncogenes isoform X1

UniProtKB/Swiss-Prot

O35158

UniProtKB/TrEMBL

A6JYK5, G3V7K7

Conserved Domains (6) summary

smart00408
Location:236 → 294

IGc2; Immunoglobulin C-2 Type

cd00063
Location:718 → 808

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:588 → 663

fn3; Fibronectin type III domain

pfam07679
Location:405 → 517

I-set; Immunoglobulin I-set domain

cd00096
Location:28 → 31

Ig; Ig strand A [structural motif]

cl11960
Location:28 → 113

Ig; Immunoglobulin domain