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    Tm2d3 TM2 domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 68634, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tm2d3provided by MGI
    Official Full Name
    TM2 domain containing 3provided by MGI
    Primary source
    MGI:MGI:1915884
    See related
    Ensembl:ENSMUSG00000078681 AllianceGenome:MGI:1915884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Blp2; 1110025I09Rik; 5930422O05Rik
    Summary
    Predicted to be involved in lateral inhibition. Predicted to be located in membrane. Orthologous to human TM2D3 (TM2 domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 55.3), ovary adult (RPKM 37.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tm2d3 in Genome Data Viewer
    Location:
    7 C; 7 35.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (65343204..65351650)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (65693417..65701913)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene threonyl-tRNA synthetase 3 Neighboring gene predicted gene, 51484 Neighboring gene predicted gene, 33234 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 51485

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors. Masuda W, et al. Sci Rep, 2023 Nov 27. PMID 38016980, Free PMC Article
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lateral inhibition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lateral inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TM2 domain-containing protein 3
    Names
    BBP-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001403392.1 → NP_001390321.1  TM2 domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122184

    2. NM_001403393.1 → NP_001390322.1  TM2 domain-containing protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122184
      UniProtKB/TrEMBL
      A0A0U1RNE7
      Related
      ENSMUSP00000145534.2, ENSMUST00000206517.2

    3. NM_001403394.1 → NP_001390323.1  TM2 domain-containing protein 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122184

    4. NM_001403395.1 → NP_001390324.1  TM2 domain-containing protein 3 isoform 6 precursor

      Status: VALIDATED

      Source sequence(s)
      AC122184

    5. NM_026795.4 → NP_081071.1  TM2 domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_081071.1

      Status: VALIDATED

      Source sequence(s)
      AC122184
      Consensus CDS
      CCDS21340.1
      UniProtKB/Swiss-Prot
      Q8BJ83
      Related
      ENSMUSP00000032726.8, ENSMUST00000032726.14
      Conserved Domains (1) summary
      pfam05154
      Location:165 → 214
      TM2; TM2 domain

    6. NM_178056.4 → NP_835157.1  TM2 domain-containing protein 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_835157.1

      Status: VALIDATED

      Source sequence(s)
      AC122184
      Consensus CDS
      CCDS21341.1
      UniProtKB/Swiss-Prot
      Q8BJ83, Q9D156
      Related
      ENSMUSP00000103119.4, ENSMUST00000107495.5
      Conserved Domains (1) summary
      pfam05154
      Location:196 → 245
      TM2; TM2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      65343204..65351650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BJ83.1 GenPept UniProtKB/Swiss-Prot:Q8BJ83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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