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    pnut peanut [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35801, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pnutprovided by FlyBase
    Official Full Name
    peanutprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013726
    Locus tag
    Dmel_CG8705
    See related
    AllianceGenome:FB:FBgn0013726
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.18; CG8705; clone 2.18; Dmel\CG8705; dSEPT7; E(sina)44C; E(sina)8; l(2)02502; Peanut; pnt; Pnut; PNUT
    Summary
    Enables several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein homodimerization activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; mitotic cytokinesis; and positive regulation of imaginal disc growth. Located in cleavage furrow; contractile ring; and intercellular bridge. Part of septin complex. Is expressed in adult head; central nervous system; follicle cell; furrow canal; and photoreceptor neurons. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See pnut in Genome Data Viewer
    Location:
    44C2-44C2; 2-58 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8237271..8240297)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4124776..4127802)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44275 Neighboring gene stable intronic sequence RNA CR46360 Neighboring gene deadpan Neighboring gene stable intronic sequence RNA 4 Neighboring gene long non-coding RNA:CR44276 Neighboring gene long non-coding RNA:CR44445

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Analysis of Phenotypic Manifestation of peanut Gene Expression Suppression by RNAi in Drosophila Oogenesis]. Akhmetova KA, et al. Genetika, 2015 Sep. PMID 26606795, Free PMC Article
    2. The Role of Pnut and its Functional Domains in Drosophila Spermatogenesis. Akhmetova KA, et al. Russ J Genet Appl Res, 2017 Jan. PMID 34306739, Free PMC Article
    3. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. Field CM, et al. J Cell Biol, 1996 May. PMID 8636235, Free PMC Article
    4. Purification and assay of a septin complex from Drosophila embryos. Oegema K, et al. Methods Enzymol, 1998. PMID 9751888
    5. Purification of cytoskeletal proteins using peptide antibodies. Field CM, et al. Methods Enzymol, 1998. PMID 9751906

    See all (193) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of Pnut in the early stages of Drosophila embryo development affects association of the Sep1-Sep2 complex with the membrane and is important for viability.
      Title: Phosphorylation of Pnut in the Early Stages of Drosophila Embryo Development Affects Association of the Septin Complex with the Membrane and Is Important for Viability.
    2. No oogenesis violations were observed in females with decreased peanut gene expression or an absence of the Pnut protein in the ovary generative cells
      Title: [Analysis of Phenotypic Manifestation of peanut Gene Expression Suppression by RNAi in Drosophila Oogenesis].
    3. These results show that the interaction of Orc6 with the septin complex is dependent on the coiled-coil domain of Pnut, and suggest an active role for Orc6 in septin complex function.
      Title: Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex.
    4. anillin and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
      Title: Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.
    5. Peanut is ubiquinated by Parkin and has a role in the neural cell death of autosomal recessive juvenile parkinsonism.
      Title: Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellularization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    peanut
    Names
    CG8705-PA
    CG8705-PB
    enhancer of seven in absentia 8
    pnut-PA
    pnut-PB
    septin
    septin 3
    septin 7
    septin[Pnut]

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8237271..8240297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165597.2 → NP_724659.1  peanut, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724659.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40797, Q0E9F5, Q9V385
      Related
      FBpp0087869
      Conserved Domains (2) summary
      COG5019
      Location:121 → 482
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:139 → 411
      Septin; Septin

    2. NM_057716.4 → NP_477064.1  peanut, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477064.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40797, Q0E9F5, Q9V385
      Related
      FBpp0087870
      Conserved Domains (2) summary
      COG5019
      Location:121 → 482
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:139 → 411
      Septin; Septin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40797.2 P40797

    Gene LinkOut

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