Socs6 suppressor of cytokine signaling 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Socs6provided by MGI
Official Full Name: suppressor of cytokine signaling 6provided by MGI
Primary source: MGI:MGI:1924885
See related: Ensembl:ENSMUSG00000056153 AllianceGenome:MGI:1924885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cis4; SSI4; Cish4; STAI4; Socs4; SOCS-4; SOCS-6; STATI4; HSPC060; 1500012M23Rik; 5830401B18Rik
Summary: Predicted to enable signaling adaptor activity. Acts upstream of or within negative regulation of T cell activation and regulation of growth. Predicted to be located in immunological synapse. Is expressed in several structures, including jaw; medulla oblongata basal plate mantle layer; and retina. Orthologous to human SOCS6 (suppressor of cytokine signaling 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.2), placenta adult (RPKM 4.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E4; 18 58.66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (88883293..88912623, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (88865169..88894364, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte Apoptosis and Is Negatively Regulated by Quaking-Mediated miR-19b.
Title: SOCS6 Promotes Mitochondrial Fission and Cardiomyocyte Apoptosis and Is Negatively Regulated by Quaking-Mediated miR-19b.
Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex.
Title: Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7.
Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6
Title: Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation.
SOCS6 has a role as a negative regulator of receptor tyrosine kinases
Title: Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.
TH1-specific chromatin structure is created by early recruitment of Swi-SNF complexes and nucleosome remodeling dependent on Stat4.
Title: T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent.
SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase
Title: Insulin induces SOCS-6 expression and its binding to the p85 monomer of phosphoinositide 3-kinase, resulting in improvement in glucose metabolism.
SOCS4 expression, in contrast, does not appear to be EPO inducible.SOCS4 is ineffective at counteracting EPO-mediated events.
Title: Differential roles of SOCS family members in EpoR signal transduction.
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6)
Title: SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Socs6 (e-PCR), detects polymorphism
- UniSTS:508513

Socs6 (e-PCR), detects polymorphism
- UniSTS:508514

STS-N33129 (e-PCR)
- UniSTS:71781

AI447482 (e-PCR)
- UniSTS:166111

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within intracellular glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: suppressor of cytokine signaling 6

Names: CIS-4; SH2 domain containing SOCS box protein SOCS6; cytokine inducible SH2-containing protein 4; cytokine inducible SH2-containing protein CIS4; cytokine-inducible SH2 protein 4; suppressor of cytokine signaling 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018821.5 → NP_061291.2 suppressor of cytokine signaling 6

See identical proteins and their annotated locations for NP_061291.2

Status: VALIDATED

Source sequence(s)

AC122398

Consensus CDS

CCDS29389.1

UniProtKB/Swiss-Prot

Q8VEN5, Q9D2A0, Q9JLY0

UniProtKB/TrEMBL

Q5U469

Related

ENSMUSP00000064929.6, ENSMUST00000070116.12

Conserved Domains (2) summary

cd10387
Location:371 → 470

SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03740
Location:493 → 533

SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

88883293..88912623 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526513.4 → XP_006526576.1 suppressor of cytokine signaling 6 isoform X1

See identical proteins and their annotated locations for XP_006526576.1

UniProtKB/Swiss-Prot

Q8VEN5, Q9D2A0, Q9JLY0

UniProtKB/TrEMBL

Q5U469

Related

ENSMUSP00000114993.2, ENSMUST00000123826.2

Conserved Domains (2) summary

cd10387
Location:371 → 470

SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03740
Location:493 → 533

SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
XM_030250541.2 → XP_030106401.1 suppressor of cytokine signaling 6 isoform X1

UniProtKB/Swiss-Prot

Q8VEN5, Q9D2A0, Q9JLY0

UniProtKB/TrEMBL

Q5U469

Conserved Domains (2) summary

cd10387
Location:371 → 470

SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03740
Location:493 → 533

SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
XM_011247090.4 → XP_011245392.1 suppressor of cytokine signaling 6 isoform X1

See identical proteins and their annotated locations for XP_011245392.1

UniProtKB/Swiss-Prot

Q8VEN5, Q9D2A0, Q9JLY0

UniProtKB/TrEMBL

Q5U469

Conserved Domains (2) summary

cd10387
Location:371 → 470

SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03740
Location:493 → 533

SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
XM_011247089.3 → XP_011245391.1 suppressor of cytokine signaling 6 isoform X1

See identical proteins and their annotated locations for XP_011245391.1

UniProtKB/Swiss-Prot

Q8VEN5, Q9D2A0, Q9JLY0

UniProtKB/TrEMBL

Q5U469

Related

ENSMUSP00000118764.2, ENSMUST00000125362.8

Conserved Domains (2) summary

cd10387
Location:371 → 470

SH2_SOCS6; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cd03740
Location:493 → 533

SOCS_SOCS6; SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...