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    Tango2 transport and golgi organization 2 [ Mus musculus (house mouse) ]

    Gene ID: 27883, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tango2provided by MGI
    Official Full Name
    transport and golgi organization 2provided by MGI
    Primary source
    MGI:MGI:101825
    See related
    Ensembl:ENSMUSG00000013539 AllianceGenome:MGI:101825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T10; D16H22S680E
    Summary
    Predicted to be involved in Golgi organization and protein secretion. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; branchial arch; cardiovascular system; and limb bud. Human ortholog(s) of this gene implicated in TANGO2-related metabolic encephalopathy and arrythmias. Orthologous to human TANGO2 (transport and golgi organization 2 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 19.8), kidney adult (RPKM 10.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tango2 in Genome Data Viewer
    Location:
    16 A3; 16 11.34 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18118689..18165962, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18300825..18348098, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DGCR8, microprocessor complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E1921 Neighboring gene microRNA 1306 Neighboring gene microRNA 3618 Neighboring gene microRNA 185 Neighboring gene STARR-positive B cell enhancer ABC_E10891 Neighboring gene armadillo repeat gene deleted in velocardiofacial syndrome Neighboring gene STARR-seq mESC enhancer starr_40280 Neighboring gene predicted gene 15764 Neighboring gene catechol-O-methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy. Kremer LS, et al. Am J Hum Genet, 2016 Feb 4. PMID 26805782, Free PMC Article
    2. A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11. McKie JM, et al. Hum Genet, 1997 Nov. PMID 9385360
    3. Gene dosage in the developing and adult brain in a mouse model of 22q11 deletion syndrome. Meechan DW, et al. Mol Cell Neurosci, 2006 Dec. PMID 17097888
    4. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Maynard TM, et al. Mol Cell Neurosci, 2008 Nov. PMID 18775783, Free PMC Article
    5. Cloning and comparative mapping of the DiGeorge syndrome critical region in the mouse. Sutherland HF, et al. Genomics, 1998 Aug 15. PMID 9740669

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transport and Golgi organization 2 homolog
    Names
    ser/Thr-rich protein T10 in DGCR region
    transport and golgi organization 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359108.1 → NP_001346037.1  transport and Golgi organization 2 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
      Source sequence(s)
      AC084822
      Consensus CDS
      CCDS28019.1
      UniProtKB/Swiss-Prot
      P54797, Q8BTN3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    2. NM_001359109.1 → NP_001346038.1  transport and Golgi organization 2 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform.
      Source sequence(s)
      AC084822
      Consensus CDS
      CCDS28019.1
      UniProtKB/Swiss-Prot
      P54797, Q8BTN3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    3. NM_001359110.1 → NP_001346039.1  transport and Golgi organization 2 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084822
      Conserved Domains (1) summary
      pfam05742
      Location:2 → 208
      TANGO2; Transport and Golgi organisation 2

    4. NM_001359111.1 → NP_001346040.1  transport and Golgi organization 2 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084822
      Conserved Domains (1) summary
      pfam05742
      Location:2 → 208
      TANGO2; Transport and Golgi organisation 2

    5. NM_138583.2 → NP_613049.2  transport and Golgi organization 2 homolog isoform 1

      See identical proteins and their annotated locations for NP_613049.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 3 encode the same isoform.
      Source sequence(s)
      AI837283, AK168595, BY274949
      Consensus CDS
      CCDS28019.1
      UniProtKB/Swiss-Prot
      P54797, Q8BTN3
      Related
      ENSMUSP00000111291.3, ENSMUST00000115628.10
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      18118689..18165962 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522230.2 → XP_006522293.1  transport and Golgi organization 2 homolog isoform X2

      See identical proteins and their annotated locations for XP_006522293.1

      Conserved Domains (1) summary
      pfam05742
      Location:2 → 208
      TANGO2; Transport and Golgi organisation 2

    2. XM_036159979.1 → XP_036015872.1  transport and Golgi organization 2 homolog isoform X1

      UniProtKB/Swiss-Prot
      P54797, Q8BTN3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    3. XM_017317031.3 → XP_017172520.1  transport and Golgi organization 2 homolog isoform X1

      UniProtKB/Swiss-Prot
      P54797, Q8BTN3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    4. XM_036159978.1 → XP_036015871.1  transport and Golgi organization 2 homolog isoform X1

      UniProtKB/Swiss-Prot
      P54797, Q8BTN3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    5. XM_011245929.1 → XP_011244231.1  transport and Golgi organization 2 homolog isoform X1

      See identical proteins and their annotated locations for XP_011244231.1

      UniProtKB/Swiss-Prot
      P54797, Q8BTN3
      Conserved Domains (1) summary
      pfam05742
      Location:1 → 259
      TANGO2; Transport and Golgi organisation 2

    RNA

    1. XR_384570.2 RNA Sequence

    2. XR_003951794.2 RNA Sequence

      Related
      ENSMUST00000128580.8

    3. XR_384571.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54797.2 GenPept UniProtKB/Swiss-Prot:P54797

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