U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Nvl nuclear VCP-like [ Mus musculus (house mouse) ]

    Gene ID: 67459, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nvlprovided by MGI
    Official Full Name
    nuclear VCP-likeprovided by MGI
    Primary source
    MGI:MGI:1914709
    See related
    Ensembl:ENSMUSG00000026516 AllianceGenome:MGI:1914709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1200009I24Rik
    Summary
    Predicted to enable ATP binding activity; ATP hydrolysis activity; and preribosome binding activity. Predicted to be involved in rRNA processing; regulation of protein localization to nucleolus; and ribosomal large subunit biogenesis. Predicted to be located in nucleoplasm. Predicted to be part of nuclear exosome (RNase complex) and telomerase holoenzyme complex. Predicted to be active in nucleus. Predicted to colocalize with nucleolus. Orthologous to human NVL (nuclear VCP like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 9.1), CNS E14 (RPKM 8.2) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nvl in Genome Data Viewer
    Location:
    1 H4; 1 84.53 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (180914703..180974557, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181087138..181144214, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 37406 Neighboring gene degenerative spermatocyte homolog 1 pseudogene Neighboring gene fibroblast growth factor receptor 3, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2593 Neighboring gene STARR-positive B cell enhancer ABC_E2026 Neighboring gene cornichon family AMPA receptor auxiliary protein 4 Neighboring gene WD repeat domain 26 Neighboring gene predicted gene, 50602

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1/WDR74 Important for Localization and Interaction with Rix7/NVL2. Lo YH, et al. Structure, 2017 May 2. PMID 28416111, Free PMC Article
    2. TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation. Fan X, et al. Elife, 2021 Feb 8. PMID 33554859, Free PMC Article
    3. RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity. Nitzsche A, et al. PLoS One, 2011 May 12. PMID 21589869, Free PMC Article
    4. Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism. Valdez-Sinon AN, et al. iScience, 2020 May 22. PMID 32434143, Free PMC Article
    5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables preribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables preribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables preribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of telomere maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein localization to nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization to nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in telomerase holoenzyme complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    colocalizes_with nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of telomerase holoenzyme complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nuclear valosin-containing protein-like

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026171.2 → NP_080447.1  nuclear valosin-containing protein-like

      See identical proteins and their annotated locations for NP_080447.1

      Status: VALIDATED

      Source sequence(s)
      AC119911, AK140509, BY793394
      Consensus CDS
      CCDS15581.1
      UniProtKB/Swiss-Prot
      Q3USC4, Q8BW27, Q8K2B5, Q9DBY8
      Related
      ENSMUSP00000027797.8, ENSMUST00000027797.9
      Conserved Domains (3) summary
      COG0464
      Location:283 → 842
      SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
      pfam00004
      Location:617 → 747
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam16725
      Location:2 → 72
      Nucleolin_bd; Nucleolin binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      180914703..180974557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496964.4 → XP_006497027.1  nuclear valosin-containing protein-like isoform X2

      Conserved Domains (1) summary
      TIGR01243
      Location:137 → 750
      CDC48; AAA family ATPase, CDC48 subfamily

    2. XM_011238856.3 → XP_011237158.1  nuclear valosin-containing protein-like isoform X1

      Conserved Domains (2) summary
      TIGR01243
      Location:220 → 833
      CDC48; AAA family ATPase, CDC48 subfamily
      pfam16725
      Location:24 → 50
      Nucleolin_bd; Nucleolin binding domain

    3. XM_030242438.2 → XP_030098298.1  nuclear valosin-containing protein-like isoform X3

      Conserved Domains (1) summary
      TIGR01243
      Location:125 → 738
      CDC48; AAA family ATPase, CDC48 subfamily

    4. XM_011238857.4 → XP_011237159.1  nuclear valosin-containing protein-like isoform X3

      Conserved Domains (1) summary
      TIGR01243
      Location:125 → 738
      CDC48; AAA family ATPase, CDC48 subfamily

    5. XM_036153140.1 → XP_036009033.1  nuclear valosin-containing protein-like isoform X2

      Conserved Domains (1) summary
      TIGR01243
      Location:137 → 750
      CDC48; AAA family ATPase, CDC48 subfamily

    6. XM_036153141.1 → XP_036009034.1  nuclear valosin-containing protein-like isoform X3

      Conserved Domains (1) summary
      TIGR01243
      Location:125 → 738
      CDC48; AAA family ATPase, CDC48 subfamily

    RNA

    1. XR_004934115.1 RNA Sequence

    2. XR_003946443.2 RNA Sequence

    3. XR_373614.5 RNA Sequence

    4. XR_003946442.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBY8.1 GenPept UniProtKB/Swiss-Prot:Q9DBY8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools