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    RGLG2 RING domain ligase2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831293, updated on 7-Sep-2023

    Summary

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    Gene symbol
    RGLG2
    Gene description
    RING domain ligase2
    Primary source
    Araport:AT5G14420
    Locus tag
    AT5G14420
    See related
    TAIR:AT5G14420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18O22.210; F18O22_210; RING domain ligase2
    Summary
    Encodes RGLG2 (RING domain ligase 2), a RING domain ubiquitin E3 ligase that negatively regulates the drought stress response by mediating ERF53 transcriptional activity.
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    Genomic context

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    See RGLG2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (4648081..4651442, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 724, subfamily A, polypeptide 1 Neighboring gene uncharacterized protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Surfeit locus protein 2 (SURF2) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2). Pan IC, et al. Mol Cell Proteomics, 2015 Oct. PMID 26253232, Free PMC Article
    2. RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis. Yu J, et al. J Integr Plant Biol, 2021 Mar. PMID 32970364
    3. Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response. Cheng MC, et al. Plant Physiol, 2012 Jan. PMID 22095047, Free PMC Article
    4. Ubiquitin lysine 63 chain forming ligases regulate apical dominance in Arabidopsis. Yin XJ, et al. Plant Cell, 2007 Jun. PMID 17586653, Free PMC Article
    5. Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis. Stone SL, et al. Plant Physiol, 2005 Jan. PMID 15644464, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis.
      Title: RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis.
    2. Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2
      Title: Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2).
    3. RGLG2 negatively regulates the drought stress response by mediating AtERF53 transcriptional activity in Arabidopsis.
      Title: Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121446.5
    NM_180487.4
    NM_203050.3
    NM_203051.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinin metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of response to water deprivation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING domain ligase2
    NP_196946.1
    • RING domain ligase2 (RGLG2); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: N-terminal protein myristoylation, cytokinin metabolic process, auxin metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 2368 Blast hits to 2301 proteins in 208 species: Archae - 0; Bacteria - 31; Metazoa - 1318; Fungi - 57; Plants - 528; Viruses - 55; Other Eukaryotes - 379 (source: NCBI BLink).
    NP_850818.1
    • RING domain ligase2 (RGLG2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 2368 Blast hits to 2301 proteins in 208 species: Archae - 0; Bacteria - 31; Metazoa - 1318; Fungi - 57; Plants - 528; Viruses - 55; Other Eukaryotes - 379 (source: NCBI BLink).
    NP_974779.1
    • RING domain ligase2 (RGLG2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_974780.1
    • RING domain ligase2 (RGLG2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4648081..4651442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_203051.3 → NP_974780.1  RING domain ligase2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LY87
      UniProtKB/TrEMBL
      B9DGM7
      Conserved Domains (2) summary
      pfam13920
      Location:421 → 464
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl00057
      Location:99 → 349
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_121446.5 → NP_196946.1  RING domain ligase2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196946.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LY87
      UniProtKB/TrEMBL
      B9DGM7
      Conserved Domains (2) summary
      pfam13920
      Location:421 → 464
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl00057
      Location:99 → 349
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. NM_203050.3 → NP_974779.1  RING domain ligase2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LY87
      UniProtKB/TrEMBL
      B9DGM7
      Conserved Domains (2) summary
      pfam13920
      Location:421 → 464
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl00057
      Location:99 → 349
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. NM_180487.4 → NP_850818.1  RING domain ligase2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LY87
      UniProtKB/TrEMBL
      B9DGM7
      Conserved Domains (2) summary
      pfam13920
      Location:421 → 464
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cl00057
      Location:99 → 349
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LY87.1

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