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    Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 [ Mus musculus (house mouse) ]

    Gene ID: 11671, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Aldh3a2provided by MGI
    Official Full Name
    aldehyde dehydrogenase family 3, subfamily A2provided by MGI
    Primary source
    MGI:MGI:1353452
    See related
    Ensembl:ENSMUSG00000010025 AllianceGenome:MGI:1353452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ahd3; Ahd-3; Aldh4; FALDH; Ahd-3r; Ahd3-r; Aldh4-r
    Summary
    Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including hexadecanal metabolic process; nervous system development; and terpenoid metabolic process. Located in endoplasmic reticulum and membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 28.8), liver E18 (RPKM 13.6) and 28 other tissues See more
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    Genomic context

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    See Aldh3a2 in Genome Data Viewer
    Location:
    11 B2; 11 37.96 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61114240..61158267, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61223417..61267528, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13, pseudogene 5 Neighboring gene aldehyde dehydrogenase family 3, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929 Neighboring gene solute carrier family 47, member 1 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetics and ontogeny of aldehyde dehydrogenase isozymes in th mouse: evidence for a locus controlling the inducibility of the liver microsomal isozyme. Timms GP, et al. Biochem Genet, 1981 Dec. PMID 7337695
    2. Genomic organization, expression, and alternate splicing of the mouse fatty aldehyde dehydrogenase gene. Lin Z, et al. Mol Genet Metab, 2000 Nov. PMID 11073717
    3. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. Kanetake T, et al. FASEB J, 2019 Jan. PMID 30085884
    4. Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery. Naganuma T, et al. J Biol Chem, 2016 May 27. PMID 27053112, Free PMC Article
    5. Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin. Demozay D, et al. J Biol Chem, 2004 Feb 20. PMID 14638678

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome.
      Title: Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjögren-Larsson Syndrome.
    2. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
      Title: Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
    3. Disruption of the Sjogren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
      Title: Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
    4. FALDH has roles in insulin action and is deregulated in states associated with altered insulin signaling
      Title: Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-chloroallyl aldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-chloroallyl aldehyde dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables long-chain fatty aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables long-chain-alcohol oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular aldehyde metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cellular aldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formaldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hexadecanal metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hexadecanal metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peripheral nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phytol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sesquiterpenoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase family 3 member A2
    Names
    alcohol dehydrogenase family 3, subfamily A2
    aldehyde dehydrogenase 3
    aldehyde dehydrogenase 4, liver microsomal (class 3) regulator
    fatty aldehyde dehydrogenase variant form
    NP_001318043.1
    NP_001318044.1
    NP_001404235.1
    NP_031463.2
    XP_006532093.1
    XP_006532094.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331114.2 → NP_001318043.1  aldehyde dehydrogenase family 3 member A2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL672172
      UniProtKB/TrEMBL
      Q99PH4
      Conserved Domains (1) summary
      cd07132
      Location:5 → 444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    2. NM_001331115.2 → NP_001318044.1  aldehyde dehydrogenase family 3 member A2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AL672172
      UniProtKB/TrEMBL
      Q99PH4
      Conserved Domains (1) summary
      cl11961
      Location:1 → 374
      ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

    3. NM_001417306.1 → NP_001404235.1  aldehyde dehydrogenase family 3 member A2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672172

    4. NM_007437.6 → NP_031463.2  aldehyde dehydrogenase family 3 member A2 isoform 2

      See identical proteins and their annotated locations for NP_031463.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon resulting in a frameshift, and differs in the 3' UTR. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL672172
      Consensus CDS
      CCDS24809.1
      UniProtKB/Swiss-Prot
      P47740, Q99L64
      UniProtKB/TrEMBL
      Q3U7B5, Q8C3C9
      Related
      ENSMUSP00000073764.8, ENSMUST00000074127.14
      Conserved Domains (1) summary
      cd07132
      Location:5 → 444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RNA

    1. NR_138545.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL646093, AL672172

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61114240..61158267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532031.5 → XP_006532094.1  aldehyde dehydrogenase family 3 member A2 isoform X2

      UniProtKB/TrEMBL
      Q3U7B5, Q8C3C9
      Conserved Domains (1) summary
      cd07132
      Location:5 → 444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    2. XM_006532030.5 → XP_006532093.1  aldehyde dehydrogenase family 3 member A2 isoform X1

      UniProtKB/TrEMBL
      B1AV77, Q8BQ93
      Related
      ENSMUSP00000104355.3, ENSMUST00000108715.3
      Conserved Domains (1) summary
      cd07132
      Location:5 → 444
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    RNA

    1. XR_388332.5 RNA Sequence

    2. XR_388331.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47740.2 GenPept UniProtKB/Swiss-Prot:P47740

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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