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    Acad11 acyl-Coenzyme A dehydrogenase family, member 11 [ Mus musculus (house mouse) ]

    Gene ID: 102632, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Acad11provided by MGI
    Official Full Name
    acyl-Coenzyme A dehydrogenase family, member 11provided by MGI
    Primary source
    MGI:MGI:2143169
    See related
    Ensembl:ENSMUSG00000090150 AllianceGenome:MGI:2143169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730439E10Rik
    Summary
    Predicted to enable long-chain fatty acyl-CoA dehydrogenase activity; medium-chain fatty acyl-CoA dehydrogenase activity; and very-long-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Located in mitochondrion. Is expressed in central nervous system and retina. Orthologous to human ACAD11 (acyl-CoA dehydrogenase family member 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver adult (RPKM 65.5), kidney adult (RPKM 50.8) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acad11 in Genome Data Viewer
    Location:
    9 F1; 9 56.25 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103940923..104004855)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (104063724..104127656)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene NSA2 ribosome biogenesis homolog pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:103965595-103965778 Neighboring gene STARR-seq mESC enhancer starr_25105 Neighboring gene ubiquitin-like modifier activating enzyme 5 Neighboring gene STARR-seq mESC enhancer starr_25106 Neighboring gene atypical chemokine receptor 4 Neighboring gene STARR-seq mESC enhancer starr_25110 Neighboring gene DnaJ heat shock protein family (Hsp40) member C13 Neighboring gene high mobility group box 1, related sequence 16 Neighboring gene predicted gene, 46130

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Olbrich H, et al. Nat Genet, 2003 Aug. PMID 12872122
    2. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Mulligan MK, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16618939, Free PMC Article
    3. Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. El-Saafin F, et al. Cell Death Differ, 2022 May. PMID 35361962, Free PMC Article
    4. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
    5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: Nphp3

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acyl-CoA dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables medium-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA dehydrogenase ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA dehydrogenase family member 11
    NP_780533.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175324.4 → NP_780533.2  acyl-CoA dehydrogenase family member 11

      See identical proteins and their annotated locations for NP_780533.2

      Status: VALIDATED

      Source sequence(s)
      AI843434, AK077531
      Consensus CDS
      CCDS23458.1
      UniProtKB/Swiss-Prot
      Q80XL6, Q8BK19
      UniProtKB/TrEMBL
      A0A0R4J0I6
      Related
      ENSMUSP00000043424.6, ENSMUST00000047799.13
      Conserved Domains (3) summary
      cd01155
      Location:376 → 769
      ACAD_FadE2; Acyl-CoA dehydrogenases similar to fadE2
      PLN02876
      Location:6 → 769
      PLN02876; acyl-CoA dehydrogenase
      cd05154
      Location:42 → 292
      ACAD10_11_N-like; N-terminal domain of Acyl-CoA dehydrogenase (ACAD) 10 and 11, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      103940923..104004855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XL6.2 GenPept UniProtKB/Swiss-Prot:Q80XL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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