Mrps6 mitochondrial ribosomal protein S6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrps6provided by MGI
Official Full Name: mitochondrial ribosomal protein S6provided by MGI
Primary source: MGI:MGI:2153111
See related: Ensembl:ENSMUSG00000039680 AllianceGenome:MGI:2153111
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable small ribosomal subunit rRNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and sensory organ. Orthologous to human MRPS6 (mitochondrial ribosomal protein S6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in genital fat pad adult (RPKM 60.3), placenta adult (RPKM 42.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 53.44 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (91855224..91909115)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (92058336..92112227)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response.
Title: MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response.
Mrps6 gene expression may not be contingent on function of Slc5a3 gene, while inositide deficiency may not be the cause of lethal apnea in null Slc5a3 mice.
Title: Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW046321 (e-PCR)
- UniSTS:164613

Mrps6 (e-PCR), detects polymorphism
- UniSTS:259107

Mrps6 (e-PCR), detects polymorphism
- UniSTS:259634

UniSTS:259143 (e-PCR)
- UniSTS:259143

Slc5a3 (e-PCR), detects polymorphism
- UniSTS:259143

Slc5a3 (e-PCR), detects polymorphism
- UniSTS:259658

AU015881 (e-PCR)
- UniSTS:209250

NoName (e-PCR)
- UniSTS:237546

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables rRNA binding	IEA Inferred from Electronic Annotation more info
enables small ribosomal subunit rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitochondrial translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	NAS Non-traceable Author Statement more info	PubMed
part_of mitochondrial small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of mitochondrial small ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of mitochondrial small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: small ribosomal subunit protein bS6m

Names: 28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.