U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    ASP1 asparaginase ASP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851920, updated on 3-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ASP1
    Official Full Name
    asparaginase ASP1
    Primary source
    SGD:S000002729
    Locus tag
    YDR321W
    See related
    AllianceGenome:SGD:S000002729; FungiDB:YDR321W; VEuPathDB:YDR321W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables asparaginase activity. Involved in asparagine catabolic process. Predicted to be located in cytoplasm. Predicted to be active in periplasmic space. [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ASP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1108702..1109847)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Swa2p Neighboring gene Dad4p Neighboring gene mitochondrial 54S ribosomal protein YmL35 Neighboring gene F1F0 ATP synthase subunit e

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Single QTL mapping and nucleotide-level resolution of a physiologic trait in wine Saccharomyces cerevisiae strains. Marullo P, et al. FEMS Yeast Res, 2007 Sep. PMID 17537182
    2. Recombinant L-asparaginase 1 from Saccharomyces cerevisiae: an allosteric enzyme with antineoplastic activity. Costa IM, et al. Sci Rep, 2016 Nov 8. PMID 27824095, Free PMC Article
    3. Genetic and physiological relationships between L-asparaginase I and asparaginase II in Saccharomyces cerevisiae. Jones GE. J Bacteriol, 1977 Apr. PMID 323221, Free PMC Article
    4. The ASP1 gene of Saccharomyces cerevisiae, encoding the intracellular isozyme of L-asparaginase. Sinclair K, et al. Gene, 1994 Jun 24. PMID 8026756
    5. Proteomics analysis for asymmetric inheritance of preexisting proteins between mother and daughter cells in budding yeast. Okada M, et al. Genes Cells, 2017 Jun. PMID 28503907

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparaginase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables asparaginase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparaginase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asparagine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in asparagine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    asparaginase ASP1
    NP_010607.3
    • Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; has low glutaminase activity and dependence; synthesized constitutively

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1108702..1109847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180629.3 → NP_010607.3  TPA: asparaginase ASP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010607.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSV3, P38986
      UniProtKB/TrEMBL
      A6ZYS3, B3LFX6, B5VGK1, C7GWL9, C8Z5N3, G2WB60, N1PAH8
      Conserved Domains (1) summary
      TIGR00520
      Location:30 → 378
      asnASE_II; L-asparaginase, type II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38986.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools