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    hpl-2 Chromobox protein homolog hpl-2 [ Caenorhabditis elegans ]

    Gene ID: 176506, updated on 14-Nov-2024

    Summary

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    Official Symbol
    hpl-2
    Official Full Name
    Chromobox protein homolog hpl-2
    Primary source
    WormBase:WBGene00001996
    Locus tag
    CELE_K01G5.2
    See related
    AllianceGenome:WB:WBGene00001996
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables H3K27me3 modified histone binding activity and chromatin binding activity. Involved in several processes, including nematode larval development; regulation of gene expression; and reproductive structure development. Located in nuclear periphery. Is expressed widely. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See hpl-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (10752195..10755530, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative H/ACA ribonucleoprotein complex subunit 4 Neighboring gene ENhancer of Uncoordination Neighboring gene putative E3 ubiquitin-protein ligase rnf113 Neighboring gene Haloacid dehalogenase-like hydrolase domain-containing protein 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression.
      Title: Tissue-specific chromatin-binding patterns of Caenorhabditis elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression.
    2. As nuclear RNAi involves chromatin changes moderated by HPL-2, a homolog of heterochromatin protein 1 (HP1), we investigated the interaction of TDP-1 and HPL-2. We found that TDP-1 and HPL-2 interact directly and that loss of TDP-1 dramatically alters the chromatin association of HPL-2.
      Title: The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.
    3. At the genic level, HPL-2 preferentially associates with well-expressed genes, and loss of HPL-2 results in up-regulation of some binding targets and down-regulation of others.
      Title: Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.
    4. Caenorhabditis elegans heterochromatin protein like-2 (HPL-2), the homolog of heterochromatin protein 1 (HP1), down-regulates the unfolded protein response in the intestine.
      Title: The Caenorhabditis elegans HP1 family protein HPL-2 maintains ER homeostasis through the UPR and hormesis.
    5. The heterochromatin protein 1 family proteins HPL-1 and HPL-2 are dispensable for de novo centromerization even though arrays become strongly enriched for the heterochromatin-associated H3K9me3 modification over time.
      Title: Rapid de novo centromere formation occurs independently of heterochromatin protein 1 in C. elegans embryos.
    6. Caenorhabditis elegans HPL-2 links developmental plasticity, longevity and lipid metabolism.
      Title: Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
    7. Caenorhabditis elegans H1 variant his-24, hpl-1, and hpl-2 coregulate the expression of genes linked to immune response.
      Title: Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.
    8. the SynMuv gene hpl-2/HP1 has an additional function in vulva precursor cells, where it may act through target genes including LIN-39/Hox
      Title: HPL-2/HP1 prevents inappropriate vulval induction in Caenorhabditis elegans by acting in both HYP7 and vulval precursor cells.
    9. the LIN-13/HPL-2 complex may physically link a subset of the Rb related synMuv proteins to chromatin
      Title: The C. elegans HP1 homologue HPL-2 and the LIN-13 zinc finger protein form a complex implicated in vulval development.
    10. Our results show that HPL-1 and HPL-2 play both unique and redundant functions in post-embryonic development.
      Title: Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables H3K27me3 modified histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome attachment to the nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vulval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail mating organ morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in olfactory learning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vulval cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vulval cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chromobox protein homolog hpl-2
    NP_001022652.1
    • Confirmed by transcript evidence
    NP_001022653.1
    • Confirmed by transcript evidence
    NP_001022654.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10752195..10755530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027482.4 → NP_001022653.1  Chromobox protein homolog hpl-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022653.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFS9
      Conserved Domains (2) summary
      cd18960
      Location:18 → 68
      CD_HP1_like; chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup
      cl28914
      Location:109 → 153
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    2. NM_001027483.3 → NP_001022654.1  Chromobox protein homolog hpl-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3C6
      Conserved Domains (2) summary
      cd18960
      Location:18 → 68
      CD_HP1_like; chromodomain of heterochromatin protein 1 proteins, including HP1alpha, HP1beta, and HP1gamma; uncharacterized subgroup
      cl28914
      Location:109 → 153
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

    3. NM_001027481.5 → NP_001022652.1  Chromobox protein homolog hpl-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022652.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDE2, G5EFS9, Q9U3C6
      Conserved Domains (2) summary
      smart00300
      Location:109 → 169
      ChSh; Chromo Shadow Domain
      cl28914
      Location:18 → 68
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    Nucleotide Protein
    Heading Accession and Version

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