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    • Showing Current items.

    daf-36 Cholesterol 7-desaturase [ Caenorhabditis elegans ]

    Gene ID: 179422, updated on 2-Nov-2024

    Summary

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    Official Symbol
    daf-36
    Official Full Name
    Cholesterol 7-desaturase
    Primary source
    WormBase:WBGene00007536
    Locus tag
    CELE_C12D8.5
    See related
    AllianceGenome:WB:WBGene00007536
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in cholesterol metabolic process. Located in cytoplasm. Is expressed in head mesodermal cell; intestine; neurons; and seam cell. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See daf-36 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (10223513..10225710, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Uncharacterized protein Neighboring gene Transthyretin-like family protein Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Wollam J, et al. Aging Cell, 2011 Oct. PMID 21749634, Free PMC Article
    2. Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Mahanti P, et al. Cell Metab, 2014 Jan 7. PMID 24411940, Free PMC Article
    3. Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis. Wang Z, et al. Elife, 2021 Dec 7. PMID 34874004, Free PMC Article
    4. Amyloid-beta induced paralysis is reduced by cholecalciferol through inhibition of the steroid-signaling pathway in an Alzheimer model of Caenorhabditis elegans. Leiteritz A, et al. Nutr Neurosci, 2021 Feb. PMID 30905309
    5. dbl-1/TGF-β and daf-12/NHR Signaling Mediate Cell-Nonautonomous Effects of daf-16/FOXO on Starvation-Induced Developmental Arrest. Kaplan RE, et al. PLoS Genet, 2015 Dec. PMID 26656736, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DAF-36 converts cholesterol to 7-dehydrocholesterol and serves as a cholesterol 7-desaturase.
      Title: The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cholesterol 7-desaturase
    NP_505629.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10223513..10225710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073228.7 → NP_505629.2  Cholesterol 7-desaturase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505629.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17938
      Conserved Domains (1) summary
      cd03469
      Location:81 → 196
      Rieske_RO_Alpha_N; Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17938.2

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