Ptk2 protein tyrosine kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptk2provided by RGD
Official Full Name: protein tyrosine kinase 2provided by RGD
Primary source: RGD:3443
See related: EnsemblRapid:ENSRNOG00000007916 AllianceGenome:RGD:3443
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FAK; FRNK; p125FAK
Summary: Enables several functions, including identical protein binding activity; integrin binding activity; and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including cellular response to morphine; positive regulation of cell population proliferation; and regulation of cell migration. Located in several cellular components, including basolateral plasma membrane; focal adhesion; and intercalated disc. Is active in glutamatergic synapse and postsynapse. Used to study hepatocellular carcinoma; hypertension; and nephritis. Biomarker of hypertension; ischemia; and uremia. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 307.3), Kidney (RPKM 290.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (107015730..107220865, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (105126725..105331848, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (114436419..114611317, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension.
Title: Type I collagen proteolysis by matrix metalloproteinase-2 contributes to focal adhesion kinase activation and vascular smooth muscle cell proliferation in the aorta in early hypertension.
Inhibited effect of an RGD peptide hydrogel on the expression of beta1-integrin, FAK, and Akt in Tenon's capsule fibroblasts.
Title: Inhibited effect of an RGD peptide hydrogel on the expression of β1-integrin, FAK, and Akt in Tenon's capsule fibroblasts.
The laminin-211-derived PPFEGCIWN motif accelerates wound reepithelialization and increases phospho-FAK-Tyr397 and Rac1-GTP levels in a rat excisional wound splinting model.
Title: The laminin-211-derived PPFEGCIWN motif accelerates wound reepithelialization and increases phospho-FAK-Tyr397 and Rac1-GTP levels in a rat excisional wound splinting model.
Low-activity programming of the PDGFRbeta/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal dexamethasone exposure.
Title: Low-activity programming of the PDGFRβ/FAK pathway mediates H-type vessel dysplasia and high susceptibility to osteoporosis in female offspring rats after prenatal dexamethasone exposure.
Quantitative Phase Imaging of Spreading Fibroblasts Identifies the Role of Focal Adhesion Kinase in the Stabilization of the Cell Rear.
Title: Quantitative Phase Imaging of Spreading Fibroblasts Identifies the Role of Focal Adhesion Kinase in the Stabilization of the Cell Rear.
Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons.
Title: Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons.
Fibrinogen-gamma chain C-terminal products (gammaC) decreased transendothelial barrier resistance in cultured rat lung microvascular endothelial cells, accompanied by increased FAK/Src phosphorylation. Experiments with pharmacological inhibition or gene silencing of FAK showed significantly reduced gammaC-induced albumin and fluid leakage across microvessels indicating the involvement of FAK in gammaC mediated hyperper...
Title: Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments.
these findings indicated that plectin protects podocytes from ADR-induced apoptosis and F-actin cytoskeletal disruption by inhibiting integrin alpha6beta4/FAK/p38 pathway activation and that plectin may be a therapeutic target for podocyte injury-related glomerular diseases.
Title: Plectin protects podocytes from adriamycin-induced apoptosis and F-actin cytoskeletal disruption through the integrin α6β4/FAK/p38 MAPK pathway.
Loss of JAM-A increased the protein levels of p-FAK.
Title: JAM-A knockdown accelerates the proliferation and migration of human keratinocytes, and improves wound healing in rats via FAK/Erk signaling.
Results indicated matrix stiffness modulated the proliferation and differentiation of tendon derived stem cells, and the regulation effect could correlate to the activation of FAK or ERK1/2
Title: Matrix stiffness regulates the differentiation of tendon-derived stem cells through FAK-ERK1/2 activation.

Submit: New GeneRIF Correction See all GeneRIFs (127)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139110 (e-PCR)
- UniSTS:221196

PMC84535P1 (e-PCR)
- UniSTS:273445

PMC84535P3 (e-PCR)
- UniSTS:273447

RH128225 (e-PCR)
- UniSTS:211533

Ptk2 (e-PCR), detects polymorphism
- UniSTS:516687

Ptk2 (e-PCR), detects polymorphism
- UniSTS:516689

RH138184 (e-PCR)
- UniSTS:220271

RH94436 (e-PCR)
- UniSTS:119684

Ptk2 (e-PCR), detects polymorphism
- UniSTS:527508

Ptk2 (e-PCR), detects polymorphism
- UniSTS:546513

Ptk2 (e-PCR), detects polymorphism
- UniSTS:143065

Ptk2 (e-PCR), detects polymorphism
- UniSTS:143066

UniSTS:143067 (e-PCR)
- UniSTS:143067

Ptk2 (e-PCR), detects polymorphism
- UniSTS:143067

RH130965 (e-PCR)
- UniSTS:214248

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase binding	ISO Inferred from Sequence Orthology more info
enables SH2 domain binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol 3-kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to morphine	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system neuron axonogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular chloride ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of organ growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of organ growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of biological quality	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular component organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organismal process	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in response to arsenic-containing substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal complex assembly	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasodilation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: focal adhesion kinase 1

Names: FADK 1; PTK2 protein tyrosine kinase 2; focal adhesion kinase-related nonkinase; pp125FAK

NP_037213.1

EC 2.7.10.2

XP_038934403.1

EC 2.7.10.2

XP_038934405.1

EC 2.7.10.2

XP_038934408.1

EC 2.7.10.2

XP_063119113.1

EC 2.7.10.2

XP_063119114.1

EC 2.7.10.2

XP_063119115.1

EC 2.7.10.2

XP_063119116.1

EC 2.7.10.2

XP_063119117.1

EC 2.7.10.2

XP_063119118.1

EC 2.7.10.2

XP_063119119.1

EC 2.7.10.2

XP_063119120.1

EC 2.7.10.2

XP_063119121.1

EC 2.7.10.2

XP_063119122.1

EC 2.7.10.2

XP_063119124.1

EC 2.7.10.2

XP_063119125.1

EC 2.7.10.2

XP_063119126.1

EC 2.7.10.2

XP_063119127.1

EC 2.7.10.2

XP_063119128.1

EC 2.7.10.2

XP_063119129.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013081.2 → NP_037213.1 focal adhesion kinase 1

See identical proteins and their annotated locations for NP_037213.1

Status: VALIDATED

Source sequence(s)

AF020777, AI717382, CA508631, CA511845, CB713440, EV773243, JAXUCZ010000007, U43942

UniProtKB/Swiss-Prot

O35346, Q62900

UniProtKB/TrEMBL

A0A8L2Q4U8

Related

ENSRNOP00000075518.3, ENSRNOT00000079599.3

Conserved Domains (5) summary

cd05056
Location:415 → 684

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:36 → 258

B41; Band 4.1 homologues

cd13190
Location:254 → 364

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:919 → 1048

Focal_AT; Focal adhesion targeting region

pfam18038
Location:35 → 130

FERM_N_2; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

107015730..107220865 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263045.1 → XP_063119115.1 focal adhesion kinase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A8P2
XM_063263051.1 → XP_063119121.1 focal adhesion kinase 1 isoform X7

UniProtKB/TrEMBL

A0A8I6AMW1
XM_063263050.1 → XP_063119120.1 focal adhesion kinase 1 isoform X6

UniProtKB/TrEMBL

A0A0G2KAT5
XM_063263043.1 → XP_063119113.1 focal adhesion kinase 1 isoform X1

Related

ENSRNOP00000089674.2, ENSRNOT00000101944.2
XM_063263047.1 → XP_063119117.1 focal adhesion kinase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A8P2
XM_063263048.1 → XP_063119118.1 focal adhesion kinase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A8P2
XM_063263049.1 → XP_063119119.1 focal adhesion kinase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A8P2
XM_063263052.1 → XP_063119122.1 focal adhesion kinase 1 isoform X8

UniProtKB/TrEMBL

A0A8I6AH25
XM_063263054.1 → XP_063119124.1 focal adhesion kinase 1 isoform X9
XM_063263046.1 → XP_063119116.1 focal adhesion kinase 1 isoform X5

UniProtKB/TrEMBL

A0A8I6A8P2
XM_063263044.1 → XP_063119114.1 focal adhesion kinase 1 isoform X1
XM_039078480.2 → XP_038934408.1 focal adhesion kinase 1 isoform X4

UniProtKB/TrEMBL

A0A8I6A3T3

Conserved Domains (5) summary

cd05056
Location:465 → 734

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:80 → 302

B41; Band 4.1 homologues

cd13190
Location:298 → 408

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:966 → 1095

Focal_AT; Focal adhesion targeting region

pfam18038
Location:79 → 174

FERM_N_2; FERM N-terminal domain
XM_039078477.2 → XP_038934405.1 focal adhesion kinase 1 isoform X3

UniProtKB/TrEMBL

A0A8I6A3T3

Related

ENSRNOP00000095122.2, ENSRNOT00000112145.2

Conserved Domains (5) summary

cd05056
Location:472 → 741

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:80 → 302

B41; Band 4.1 homologues

cd13190
Location:298 → 408

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:973 → 1102

Focal_AT; Focal adhesion targeting region

pfam18038
Location:79 → 174

FERM_N_2; FERM N-terminal domain
XM_039078475.2 → XP_038934403.1 focal adhesion kinase 1 isoform X2

UniProtKB/TrEMBL

A0A8I6A3T3

Related

ENSRNOP00000092163.2, ENSRNOT00000113790.2

Conserved Domains (5) summary

cd05056
Location:493 → 762

PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase

smart00295
Location:80 → 302

B41; Band 4.1 homologues

cd13190
Location:298 → 408

FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2

pfam03623
Location:994 → 1123

Focal_AT; Focal adhesion targeting region

pfam18038
Location:79 → 174

FERM_N_2; FERM N-terminal domain
XM_063263057.1 → XP_063119127.1 focal adhesion kinase 1 isoform X12
XM_063263058.1 → XP_063119128.1 focal adhesion kinase 1 isoform X13
XM_063263059.1 → XP_063119129.1 focal adhesion kinase 1 isoform X13
XM_063263055.1 → XP_063119125.1 focal adhesion kinase 1 isoform X10
XM_063263056.1 → XP_063119126.1 focal adhesion kinase 1 isoform X11