Fgf1 fibroblast growth factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf1provided by MGI
Official Full Name: fibroblast growth factor 1provided by MGI
Primary source: MGI:MGI:95515
See related: Ensembl:ENSMUSG00000036585 AllianceGenome:MGI:95515
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam; Fgfa; Dffrx; Fgf-1; Fgf2b
Summary: Predicted to enable several functions, including Hsp70 protein binding activity; S100 protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including organ induction; positive regulation of epithelial cell proliferation; and positive regulation of macromolecule metabolic process. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in brain ischemia; cleft lip; myocardial infarction; schizophrenia; and urinary bladder cancer. Orthologous to human FGF1 (fibroblast growth factor 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Broad expression in lung adult (RPKM 20.2), heart adult (RPKM 15.2) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 20.74 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (38971725..39062532, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (38838672..38929470, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paracrine FGF1 signaling directs pituitary architecture and size.
Title: Paracrine FGF1 signaling directs pituitary architecture and size.
Sustained activation of the FGF1-MEK-ERK pathway inhibits proliferation, invasion and migration and enhances radiosensitivity in mouse angiosarcoma cells.
Title: Sustained activation of the FGF1-MEK-ERK pathway inhibits proliferation, invasion and migration and enhances radiosensitivity in mouse angiosarcoma cells.
FGF1[DeltaHBS] ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model.
Title: FGF1(ΔHBS) ameliorates retinal inflammation via suppressing TSPO signal in a type 2 diabetes mouse model.
FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer.
Title: FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer.
Novel Muscle-Homing Peptide FGF1 Conjugate Based on AlphaFold for Type 2 Diabetes Mellitus.
Title: Novel Muscle-Homing Peptide FGF1 Conjugate Based on AlphaFold for Type 2 Diabetes Mellitus.
nFGF1 Protects beta-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1alpha Axis.
Title: ∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis.
Autocrine FGF1 signaling promotes glucose uptake in adipocytes.
Title: Autocrine FGF1 signaling promotes glucose uptake in adipocytes.
MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling.
Title: MicroRNA-27b-3p down-regulates FGF1 and aggravates pathological cardiac remodelling.
MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis.
Title: MicroRNA-370 carried by M2 macrophage-derived exosomes alleviates asthma progression through inhibiting the FGF1/MAPK/STAT1 axis.
FGF1(DeltaHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.
Title: FGF1(ΔHBS) prevents diabetic cardiomyopathy by maintaining mitochondrial homeostasis and reducing oxidative stress via AMPK/Nur77 suppression.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fgf1 (e-PCR), detects polymorphism
- UniSTS:507912

stSG622867 (e-PCR)
- UniSTS:455466

Fgf1 (e-PCR), detects polymorphism
- UniSTS:273719

NoName (e-PCR)
- UniSTS:548164

AF067190 (e-PCR)
- UniSTS:181112

Fgf1 (e-PCR), detects polymorphism
- UniSTS:461974

PMC135637P3 (e-PCR)
- UniSTS:270764

Fgf1 (e-PCR), detects polymorphism
- UniSTS:258255

AU015741 (e-PCR)
- UniSTS:209374

Fgf1 (e-PCR), detects polymorphism
- UniSTS:478951

Fgf1 (e-PCR), detects polymorphism
- UniSTS:266996

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables S100 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase B activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase B activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in branch elongation involved in ureteric bud branching	ISO Inferred from Sequence Orthology more info
involved_in branch elongation involved in ureteric bud branching	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac muscle cell proliferation	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in cellular response to heat	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lung development	IDA Inferred from Direct Assay more info	PubMed
involved_in mesonephric epithelium development	ISO Inferred from Sequence Orthology more info
involved_in mesonephric epithelium development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within organ induction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor	IEA Inferred from Electronic Annotation more info
involved_in regulation of endothelial cell chemotaxis to fibroblast growth factor	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial tube morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in vasculogenesis involved in coronary vascular morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in wound healing	IEA Inferred from Electronic Annotation more info
involved_in wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 1

Names: HBGF-1; aFGF; acidic fibroblast growth factor; fibroblast growth factor 1 (acidic); fibroblast growth factor 2b; heparin-binding growth factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010197.3 → NP_034327.1 fibroblast growth factor 1

See identical proteins and their annotated locations for NP_034327.1

Status: VALIDATED

Source sequence(s)

AC132098, AK035330

Consensus CDS

CCDS29204.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Related

ENSMUSP00000045710.5, ENSMUST00000040647.11

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

38971725..39062532 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525647.4 → XP_006525710.1 fibroblast growth factor 1 isoform X4

See identical proteins and their annotated locations for XP_006525710.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_017317831.2 → XP_017173320.1 fibroblast growth factor 1 isoform X5

Conserved Domains (1) summary

pfam00167
Location:25 → 147

FGF; Fibroblast growth factor
XM_006525644.4 → XP_006525707.1 fibroblast growth factor 1 isoform X4

See identical proteins and their annotated locations for XP_006525707.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_036160985.1 → XP_036016878.1 fibroblast growth factor 1 isoform X4

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_011246843.3 → XP_011245145.1 fibroblast growth factor 1 isoform X4

See identical proteins and their annotated locations for XP_011245145.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_017317830.1 → XP_017173319.1 fibroblast growth factor 1 isoform X4

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_011246842.3 → XP_011245144.1 fibroblast growth factor 1 isoform X4

See identical proteins and their annotated locations for XP_011245144.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_036160986.1 → XP_036016879.1 fibroblast growth factor 1 isoform X4

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_036160987.1 → XP_036016880.1 fibroblast growth factor 1 isoform X4

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_006525648.5 → XP_006525711.1 fibroblast growth factor 1 isoform X4

See identical proteins and their annotated locations for XP_006525711.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_011246841.4 → XP_011245143.1 fibroblast growth factor 1 isoform X3

Conserved Domains (1) summary

pfam00167
Location:42 → 165

FGF; Fibroblast growth factor
XM_006525649.3 → XP_006525712.1 fibroblast growth factor 1 isoform X4

See identical proteins and their annotated locations for XP_006525712.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Related

ENSMUSP00000157968.2, ENSMUST00000236630.2

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_006525642.5 → XP_006525705.1 fibroblast growth factor 1 isoform X2

Conserved Domains (1) summary

pfam00167
Location:47 → 169

FGF; Fibroblast growth factor
XM_006525641.5 → XP_006525704.1 fibroblast growth factor 1 isoform X1

Conserved Domains (1) summary

pfam00167
Location:47 → 170

FGF; Fibroblast growth factor
XM_006525645.5 → XP_006525708.1 fibroblast growth factor 1 isoform X4

See identical proteins and their annotated locations for XP_006525708.1

UniProtKB/Swiss-Prot

P10935, P61148

UniProtKB/TrEMBL

Q6ZWS1

Related

ENSMUSP00000111245.2, ENSMUST00000115582.8

Conserved Domains (1) summary

pfam00167
Location:25 → 148

FGF; Fibroblast growth factor
XM_036160988.1 → XP_036016881.1 fibroblast growth factor 1 isoform X7

UniProtKB/TrEMBL

D6RCX9

Related

ENSMUSP00000123293.2, ENSMUST00000131348.8

Conserved Domains (1) summary

cl00060
Location:25 → 56

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
XM_017317832.3 → XP_017173321.1 fibroblast growth factor 1 isoform X6

Conserved Domains (1) summary

cl00060
Location:47 → 78

FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...