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    CG4928 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32682, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG4928provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027556
    Locus tag
    Dmel_CG4928
    See related
    AllianceGenome:FB:FBgn0027556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH10120; Dmel\CG4928
    Summary
    Predicted to enable potassium channel regulator activity and transmembrane transporter activity. Involved in inorganic ion homeostasis and renal system process. Predicted to be active in plasma membrane and striated muscle dense body. Is expressed in adult head. Orthologous to human UNC93A (unc-93 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG4928 in Genome Data Viewer
    Location:
    15C1-15C4; 1-56 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16913180..16938209)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16807213..16832242)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44754 Neighboring gene wurst Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CG4928 Is Vital for Renal Function in Fruit Flies and Membrane Potential in Cells: A First In-Depth Characterization of the Putative Solute Carrier UNC93A. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 33163493, Free PMC Article
    2. Glucose Availability Alters Gene and Protein Expression of Several Newly Classified and Putative Solute Carriers in Mice Cortex Cell Culture and D. melanogaster. Ceder MM, et al. Front Cell Dev Biol, 2020. PMID 32733888, Free PMC Article
    3. The requirement of IRE1 and XBP1 in resolving physiological stress during Drosophila development. Huang HW, et al. J Cell Sci, 2017 Sep 15. PMID 28775151, Free PMC Article
    4. FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas. Krause SA, et al. Nucleic Acids Res, 2022 Jan 7. PMID 34718735, Free PMC Article
    5. Evolutionary expressed sequence tag analysis of Drosophila female reproductive tracts identifies genes subjected to positive selection. Swanson WJ, et al. Genetics, 2004 Nov. PMID 15579698, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 16936064-16936403 mobile_element_type = transposon:jockey{}145

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inorganic ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in renal system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in striated muscle dense body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4928-PA
    CG4928-PB
    CG4928-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16913180..16938209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167552.2 → NP_728035.1  uncharacterized protein Dmel_CG4928, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728035.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHR6, Q6BD02, Q9Y115
      UniProtKB/TrEMBL
      B7Z155
      Related
      FBpp0074118
      Conserved Domains (2) summary
      cl21472
      Location:49 → 155
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cl26865
      Location:255 → 426
      MFS_1; Major Facilitator Superfamily

    2. NM_132951.3 → NP_573179.1  uncharacterized protein Dmel_CG4928, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573179.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHR6, Q6BD02, Q9Y115
      UniProtKB/TrEMBL
      B7Z155
      Related
      FBpp0074119
      Conserved Domains (2) summary
      cl21472
      Location:49 → 155
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cl26865
      Location:255 → 426
      MFS_1; Major Facilitator Superfamily

    3. NM_001298425.1 → NP_001285354.1  uncharacterized protein Dmel_CG4928, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFT8
      Conserved Domains (1) summary
      cl21472
      Location:49 → 155
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z155 B7Z155
    Q95SJ8 Q95SJ8
    Q9Y115.1 Q9Y115
    X2JFT8 X2JFT8

    Gene LinkOut

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