cldn7b claudin 7b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cldn7bprovided by ZNC
Official Full Name: claudin 7bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-001103-5
See related: Ensembl:ENSDARG00000014047 AllianceGenome:ZFIN:ZDB-GENE-001103-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb388; cldn7; fd19f08; claudin7; wu:fd19f08
Summary: Predicted to enable structural molecule activity. Acts upstream of or within several processes, including adherens junction organization; inner ear development; and sensory perception of sound. Predicted to be located in cell junction and membrane. Predicted to be integral component of membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in several structures, including EVL; digestive system; integument; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to several human genes including CLDN7 (claudin 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (22144769..22150329, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (22175317..22180846, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cldn7b is essential for the formation and proper function of inner ear
Title: Claudin7b is required for the formation and function of inner ear in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fl24g11.x1 (e-PCR)
- UniSTS:202093

fd19f08.x1 (e-PCR)
- UniSTS:204251

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otolith development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: claudin-7-B

Names: claudin-7; claudin-like protein ZF4A22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.