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    Folr2 folate receptor beta [ Mus musculus (house mouse) ]

    Gene ID: 14276, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Folr2provided by MGI
    Official Full Name
    folate receptor betaprovided by MGI
    Primary source
    MGI:MGI:95569
    See related
    Ensembl:ENSMUSG00000032725 AllianceGenome:MGI:95569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBP2; FR-P3; Folbp2; FR-beta; Folbp-2
    Summary
    This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in mammary gland adult (RPKM 34.0), subcutaneous fat pad adult (RPKM 24.0) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Folr2 in Genome Data Viewer
    Location:
    7 E2; 7 54.67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101489195..101506397, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101839988..101857190, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene paired-like homeobox 2a Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene predicted gene 10602 Neighboring gene folate receptor alpha Neighboring gene STARR-seq mESC enhancer starr_19700 Neighboring gene predicted gene, 35597

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effects of dietary folate intake and folate binding protein-2 (Folbp2) on urinary speciation of sodium arsenate in mice. Spiegelstein O, et al. Environ Toxicol Pharmacol, 2005 Jan. PMID 21783456
    2. Differential effects of arsenic on folate binding protein 2 (Folbp2) null and wild type fibroblasts. Crandall LZ, et al. Toxicol Lett, 2002 Nov 15. PMID 12368056
    3. Valproate-induced neural tube defects in folate-binding protein-2 (Folbp2) knockout mice. Spiegelstein O, et al. Birth Defects Res A Clin Mol Teratol, 2003 Dec. PMID 14745917
    4. Folate modulates Hox gene-controlled skeletal phenotypes. Kappen C, et al. Genesis, 2004 Jul. PMID 15282741, Free PMC Article
    5. Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Wlodarczyk B, et al. Toxicol Appl Pharmacol, 2001 Dec 15. PMID 11749123

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.
      Title: Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.
    2. (18)F-AzaFol for Detection of Folate Receptor-beta Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study.
      Title: (18)F-AzaFol for Detection of Folate Receptor-β Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study.
    3. The characteristics of folate transport in oocytes are consistent with folate receptor-mediated endocytosis, possibly by the FOLR2 isoform.
      Title: Growing Mouse Oocytes Transiently Activate Folate Transport via Folate Receptors As They Approach Full Size.
    4. FRbeta expression was markedly increased in lung macrophages at 48 hours after intratracheal LPS.
      Title: Molecular imaging of folate receptor β-positive macrophages during acute lung inflammation.
    5. The mRNAs encoding Folr2 and the intestinal folate transporter Slc46a1 were not detected in 2-cell embryos and blastocysts.
      Title: Folate transport in mouse cumulus-oocyte complexes and preimplantation embryos.
    6. Folbp2 null cells display increased sensitivity to arsenic exposure
      Title: Differential effects of arsenic on folate binding protein 2 (Folbp2) null and wild type fibroblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables folic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables folic acid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables folic acid receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables folic acid receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables folic acid receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to folic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sperm-egg recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    folate receptor beta
    Names
    folate binding protein 2
    folate receptor 2 (fetal)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303231.1 → NP_001290160.1  folate receptor beta precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-3) encode the same protein.
      Source sequence(s)
      AC159005
      Consensus CDS
      CCDS21516.1
      UniProtKB/Swiss-Prot
      Q05685
      Conserved Domains (1) summary
      pfam03024
      Location:29 → 203
      Folate_rec; Folate receptor family

    2. NM_001303239.1 → NP_001290168.1  folate receptor beta precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1-3) encode the same protein.
      Source sequence(s)
      AC159005, AC167240, BQ176722
      Consensus CDS
      CCDS21516.1
      UniProtKB/Swiss-Prot
      Q05685
      Related
      ENSMUSP00000147920.2, ENSMUST00000210598.2
      Conserved Domains (1) summary
      pfam03024
      Location:29 → 203
      Folate_rec; Folate receptor family

    3. NM_008035.2 → NP_032061.1  folate receptor beta precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-3) encode the same protein.
      Source sequence(s)
      AC159005, BQ176722, CJ049116
      Consensus CDS
      CCDS21516.1
      UniProtKB/Swiss-Prot
      Q05685
      Related
      ENSMUSP00000091692.6, ENSMUST00000094141.7
      Conserved Domains (1) summary
      pfam03024
      Location:29 → 203
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101489195..101506397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05685.1 GenPept UniProtKB/Swiss-Prot:Q05685

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