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    mt:Cyt-b mitochondrial Cytochrome b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 19893556, updated on 14-Nov-2024

    Summary

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    Official Symbol
    mt:Cyt-bprovided by FlyBase
    Official Full Name
    mitochondrial Cytochrome bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013678
    Locus tag
    Dmel_CG34090
    See related
    AllianceGenome:FB:FBgn0013678
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    mt:Cyt-b; CYTB
    Summary
    Predicted to contribute to ubiquinol-cytochrome-c reductase activity. Involved in spermatogenesis. Predicted to be part of respiratory chain complex III. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in ovarian carcinoma and urinary bladder cancer. Orthologous to human MT-CYB (mitochondrially encoded cytochrome b). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mt:Cyt-b in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) MT (non-nuclear) NC_024511.2 (10499..11635)

    Chromosome MT - NC_024511.2Genomic Context describing neighboring genes Neighboring gene mitochondrial transfer RNA:Proline-TGG Neighboring gene mitochondrial NADH-ubiquinone oxidoreductase chain 6 Neighboring gene mitochondrial transfer RNA:Serine-TGA Neighboring gene mitochondrial NADH-ubiquinone oxidoreductase chain 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_024511.2 Chromosome MT Reference Release 6 plus ISO1 MT non-nuclear

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitonuclear interactions, mtDNA-mediated thermal plasticity, and implications for the Trojan Female Technique for pest control. Wolff JN, et al. Sci Rep, 2016 Jul 21. PMID 27443488, Free PMC Article
    2. Functional, structural, and phylogenetic analysis of mitochondrial cytochrome b (cytb) in insects. Seddigh S, et al. Mitochondrial DNA A DNA Mapp Seq Anal, 2018 Mar. PMID 28116966
    3. Unraveling selection in the mitochondrial genome of Drosophila. Ballard JW, et al. Genetics, 1994 Nov. PMID 7851772, Free PMC Article
    4. Cytoplasmic male sterility in Drosophila melanogaster associated with a mitochondrial CYTB variant. Clancy DJ, et al. Heredity (Edinb), 2011 Oct. PMID 21407254, Free PMC Article
    5. Evolutionary divergence of the cytochrome b5 gene of Drosophila. Kula ME, et al. J Mol Evol, 1995 Oct. PMID 7563130

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to ubiquinol-cytochrome-c reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in respiratory electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex III IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b
    YP_009047277.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_024511.2 Reference assembly

      Range
      10499..11635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009047277.1 Peptide Sequence

      See identical proteins and their annotated locations for YP_009047277.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P18935
      UniProtKB/TrEMBL
      A0A0A0RVF0, A0A0M4FHJ7, A0A1S6KX53, A0A1S6KXB6, A0A1W6LRF7, A0A343ASW6, B6E0Q3, B6E0S9, B6E0W8, Q9ME01
      Related
      FBpp0390634
      Conserved Domains (1) summary
      MTH00156
      Location:12 → 367
      CYTB; cytochrome b; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18935.2 P18935
    Q9ME01 Q9ME01

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