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    mt:CoII mitochondrial Cytochrome c oxidase subunit II [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 19893535, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mt:CoIIprovided by FlyBase
    Official Full Name
    mitochondrial Cytochrome c oxidase subunit IIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013675
    Locus tag
    Dmel_CG34069
    See related
    AllianceGenome:FB:FBgn0013675
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    mt:CoII; COX2
    Summary
    Predicted to enable copper ion binding activity. Predicted to contribute to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in membrane. Predicted to be part of respiratory chain complex IV. Is expressed in adult head and spermatozoon. Orthologous to human MTCO2P12 (MT-CO2 pseudogene 12) and MT-CO2 (mitochondrially encoded cytochrome c oxidase II). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mt:CoII in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) MT (non-nuclear) NC_024511.2 (3083..3767)

    Chromosome MT - NC_024511.2Genomic Context describing neighboring genes Neighboring gene mitochondrial Cytochrome c oxidase subunit I Neighboring gene mitochondrial transfer RNA:Leucine-TAA Neighboring gene mitochondrial transfer RNA:Lysine-CTT Neighboring gene mitochondrial transfer RNA:Aspartic acid-GTC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_024511.2 Chromosome MT Reference Release 6 plus ISO1 MT non-nuclear

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitonuclear Interactions Produce Diverging Responses to Mild Stress in Drosophila Larvae. Rodríguez E, et al. Front Genet, 2021. PMID 34603395, Free PMC Article
    2. DNA barcoding of recently diverged species: relative performance of matching methods. van Velzen R, et al. PLoS One, 2012. PMID 22272356, Free PMC Article
    3. Precise annotation of Drosophila mitochondrial genomes leads to insights into AT-rich regions. Liang G, et al. Mitochondrion, 2022 Jul. PMID 35779797
    4. A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster. Patel MR, et al. Elife, 2016 Aug 2. PMID 27481326, Free PMC Article
    5. Quakes hit California and, perhaps, the central dogma. Jukes TH. J Mol Evol, 1990 Jan. PMID 2107320

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to cytochrome-c oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit II
    YP_009047268.1
    • TAA stop codon is completed by the addition of 3' A residues to the mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_024511.2 Reference assembly

      Range
      3083..3767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009047268.1 Peptide Sequence

      See identical proteins and their annotated locations for YP_009047268.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      B2L9S3, B6E0V9, P00408, Q05GI7
      UniProtKB/TrEMBL
      A0A0A0RZ60, C6KI54, J9THZ9, J9TIE4
      Related
      FBpp0100177
      Conserved Domains (1) summary
      MTH00154
      Location:1 → 227
      COX2; cytochrome c oxidase subunit II; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00408.1 P00408

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