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    LeuRS Leucyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326262, updated on 4-Jul-2024

    Summary

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    Official Symbol
    LeuRSprovided by FlyBase
    Official Full Name
    Leucyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0284253
    Locus tag
    Dmel_CG33123
    See related
    AllianceGenome:FB:FBgn0284253
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey266; CG3229; CG33123; Dmel\CG33123; l(2)SH0501; l(2)SH2 0501
    Summary
    Predicted to enable leucine-tRNA ligase activity. Involved in wound healing. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in infantile liver failure syndrome 1. Orthologous to human LARS1 (leucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See LeuRS in Genome Data Viewer
    Location:
    23F6-23F6; 2-10 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3510328..3514656, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3510328..3514656, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45299 Neighboring gene antisense RNA:CR45300 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
    2. The Neurexin/N-Ethylmaleimide-sensitive Factor (NSF) Interaction Regulates Short Term Synaptic Depression. Li T, et al. J Biol Chem, 2015 Jul 17. PMID 25953899, Free PMC Article
    3. Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA. Fox RM, et al. Development, 2013 May. PMID 23578928, Free PMC Article
    4. Vitamin A deficiency affects gene expression in the Drosophila melanogaster head. Dewett D, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849795, Free PMC Article
    5. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leucine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leucine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leucine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in leucyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leucyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in leucyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in wound healing HMP PubMed 
    Component Evidence Code Pubs
    part_of aminoacyl-tRNA synthetase multienzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucyl-tRNA synthetase
    Names
    CG33123-PA
    CG33123-PB
    LeuRS-PA
    LeuRS-PB
    lethal (2) SH0501
    NP_001285589.1
    NP_787968.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3510328..3514656 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298660.1 → NP_001285589.1  Leucyl-tRNA synthetase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285589.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQR8, T2FFJ2
      Conserved Domains (4) summary
      cd07959
      Location:756 → 876
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:525 → 758
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:1 → 1068
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:47 → 204
      nt_trans; nucleotidyl transferase superfamily

    2. NM_175954.2 → NP_787968.1  Leucyl-tRNA synthetase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQR8, T2FFJ2
      Related
      FBpp0077251
      Conserved Domains (4) summary
      cd07959
      Location:756 → 876
      Anticodon_Ia_Leu_AEc; Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases
      cd00812
      Location:525 → 758
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      PLN02959
      Location:1 → 1068
      PLN02959; aminoacyl-tRNA ligase
      cl00015
      Location:47 → 204
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRF8 Q8MRF8
    Q9VQR8 Q9VQR8

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