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    C3L secreted complement-binding protein [ Vaccinia virus ]

    Gene ID: 3707640, updated on 18-Aug-2023

    Summary

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    Gene symbol
    C3L
    Gene description
    secreted complement-binding protein
    Locus tag
    VACWR025
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Vaccinia virus (strain: WR (Western Reserve))
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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    Genomic context

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    Sequence:
    NC_006998.1 (18677..19468, complement)

    NC_006998.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene kelch-like protein Neighboring gene Hypothetical protein Neighboring gene temporal expression: early/late

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_006998.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Vaccinia virus complement control protein modulates adaptive immune responses during infection. Girgis NM, et al. J Virol, 2011 Mar. PMID 21191012, Free PMC Article
    2. Glycosylated and nonglycosylated complement control protein of the lister strain of vaccinia virus. Meseda CA, et al. Clin Vaccine Immunol, 2014 Sep. PMID 25030055, Free PMC Article
    3. Genomic sequence of a clonal isolate of the vaccinia virus Lister strain employed for smallpox vaccination in France and its comparison to other orthopoxviruses. Garcel A, et al. J Gen Virol, 2007 Jul. PMID 17554021

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    secreted complement-binding protein
    YP_232907.1
    • secreted complement-binding protein; binds host complement components C3b and C4b to modulate the host inflammatory response; blocks both classical and alternative pathways of complement activity; similar to Vaccinia virus Copenhagen C3L; the poxviridae are enveloped unsegmented dsDNA viruses; unlike many dsDNA viruses that replicate in the host nucleus poxviruses encode their own replication machinery and therefore replicate in the cytoplasm; viral genes are expressed in a bi-phasic manner with early genes genes encoding non-structural proteins involved in genome replication and late genes encoding the viral structural proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_006998.1 Reference assembly

      Range
      18677..19468 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_232907.1 secreted complement binding C3b/C4b [Vaccinia virus]

      See identical proteins and their annotated locations for YP_232907.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P10998, P68638, P68639, Q76ZY4
      UniProtKB/TrEMBL
      A0A2I2MBW6, A4GD81, A9J1F2, M9WKE1, Q1M2I1, Q49PX4, Q77TN7, S5G1Q4
      Conserved Domains (1) summary
      PHA02927
      Location:1 → 263
      PHA02927; secreted complement-binding protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAO89304.1

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