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    VHT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852956, updated on 11-Sep-2024

    Summary

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    Official Symbol
    VHT1
    Primary source
    SGD:S000003297
    Locus tag
    YGR065C
    See related
    AllianceGenome:SGD:S000003297; FungiDB:YGR065C; VEuPathDB:YGR065C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables biotin transmembrane transporter activity. Involved in biotin transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (618077..619858, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene membrane insertase COX18 Neighboring gene transcription elongation factor SPT4 Neighboring gene Gid10p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the plasma membrane H+-biotin symporter of Saccharomyces cerevisiae by rescue of a fatty acid-auxotrophic mutant. Stolz J, et al. J Biol Chem, 1999 Jun 25. PMID 10373489
    2. Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5. Weider M, et al. J Biol Chem, 2006 May 12. PMID 16533810
    3. Isolation and characterization of the plasma membrane biotin transporter from Schizosaccharomyces pombe. Stolz J. Yeast, 2003 Feb. PMID 12557275
    4. Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase. Pirner HM, et al. J Biol Chem, 2006 May 5. PMID 16531611
    5. Cell division defects of Schizosaccharomyces pombe liz1- mutants are caused by defects in pantothenate uptake. Stolz J, et al. Eukaryot Cell, 2004 Apr. PMID 15075270, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a conserved DNA element mediates biotin sensing in Saccharomyces cerevisiae with biotin-protein ligase Vht1p
      Title: Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase.
    2. The presented data characterize Vhr1p as an essential component of the biotin-dependent signal transduction cascade in yeast.
      Title: Vhr1p, a new transcription factor from budding yeast, regulates biotin-dependent expression of VHT1 and BIO5.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables biotin transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vht1p
    NP_011579.1
    • High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      618077..619858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181194.1 → NP_011579.1  TPA: Vht1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011579.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUJ9, P53241
      UniProtKB/TrEMBL
      A6ZV49, B3LIF9, C7GXP7, N1P3I8
      Conserved Domains (1) summary
      cd17327
      Location:124 → 542
      MFS_FEN2_like; Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53241.1

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