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    TIM12 Tim12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852388, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TIM12
    Official Full Name
    Tim12p
    Primary source
    SGD:S000000295
    Locus tag
    YBR091C
    See related
    AllianceGenome:SGD:S000000295; FungiDB:YBR091C; VEuPathDB:YBR091C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MRS5
    Summary
    Enables phospholipid binding activity. Contributes to protein transmembrane transporter activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Part of TIM22 mitochondrial import inner membrane insertion complex. Orthologous to human TIMM10 (translocase of inner mitochondrial membrane 10). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TIM12 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (427155..427484, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene proliferating cell nuclear antigen Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein Neighboring gene acid phosphatase PHO3 Neighboring gene acid phosphatase PHO5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mrs5p, an essential protein of the mitochondrial intermembrane space, affects protein import into yeast mitochondria. Jarosch E, et al. J Biol Chem, 1996 Jul 19. PMID 8663351
    2. A soluble 12-kDa protein of the mitochondrial intermembrane space, Mrs11p, is essential for mitochondrial biogenesis and viability of yeast cells. Jarosch E, et al. Mol Gen Genet, 1997 Jun. PMID 9236772
    3. The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain. Lionaki E, et al. J Biol Chem, 2008 Jun 6. PMID 18387953, Free PMC Article
    4. Molecular interactions of the mitochondrial Tim12 translocase subunit. Baud C, et al. Protein Pept Lett, 2007. PMID 17627602
    5. Three nuclear genes suppress a yeast mitochondrial splice defect when present in high copy number. Koll H, et al. Curr Genet, 1987. PMID 2452028

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that assembly of the three small Tim proteins, Tim9, -10, and -12, precedes docking to the mitochondrial carrier translocase.
      Title: Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase.
    2. the essential role of Tim12 relies on its unique assembly properties that allow this subunit to bridge the soluble and membrane-embedded translocases in the carrier import pathway.
      Title: The essential function of Tim12 in vivo is ensured by the assembly interactions of its C-terminal domain.
    3. study found that TIM12 forms dimers that bind to Tim9; in this interaction, Tim12 undergoes structural changes that may be important for transport of its substrates in the mitochondrial carrier import pathway
      Title: Molecular interactions of the mitochondrial Tim12 translocase subunit.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to protein transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tim12p
    NP_009649.1
    • Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      427155..427484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178439.1 → NP_009649.1  TPA: Tim12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ92, P32830
      UniProtKB/TrEMBL
      A6ZL38, B3LN60, C7GJR9, D3UEI6, G2W999, N1PAS6
      Conserved Domains (1) summary
      pfam02953
      Location:12 → 78
      zf-Tim10_DDP; Tim10/DDP family zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32830.1

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