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    OAZ1 ornithine decarboxylase antizyme 1 [ Gorilla gorilla gorilla (western lowland gorilla) ]

    Gene ID: 101137836, updated on 1-Oct-2024

    Summary

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    Gene symbol
    OAZ1
    Gene description
    ornithine decarboxylase antizyme 1
    See related
    Ensembl:ENSGGOG00000007571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Gorilla gorilla gorilla (sub-species: gorilla)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Gorilla
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014]
    Orthologs
    human mouse all
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    Genomic context

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    See OAZ1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mGorGor1-v2.0_pri (GCF_029281585.2) 20 NC_073244.2 (8044732..8048702)
    RS_2023_04 previous assembly NHGRI_mGorGor1-v1.1-0.2.freeze_pri (GCF_029281585.1) 19 NC_073243.1 (8037707..8041677)

    Chromosome 20 - NC_073244.2Genomic Context describing neighboring genes Neighboring gene anti-Mullerian hormone Neighboring gene junctional sarcoplasmic reticulum protein 1 Neighboring gene PEAK family member 3 Neighboring gene leucine rich repeat and Ig domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial localization of antizyme is determined by context-dependent alternative utilization of two AUG initiation codons. Gandre S, et al. Mitochondrion, 2003 Mar. PMID 16120325
    2. Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation. Ivanov IP, et al. Nucleic Acids Res, 2007. PMID 17332016, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291863.2 → NP_001278792.1  ornithine decarboxylase antizyme 1

      See identical proteins and their annotated locations for NP_001278792.1

      Status: REVIEWED

      Source sequence(s)
      JARGGP020000020
      UniProtKB/TrEMBL
      G3QX75
      Related
      ENSGGOP00000007409.3, ENSGGOT00000007606.3
      Conserved Domains (1) summary
      pfam02100
      Location:138 → 217
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: GCF_029281585.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mGorGor1-v2.0_pri Primary Assembly

    Genomic

    1. NC_073244.2 Reference NHGRI_mGorGor1-v2.0_pri Primary Assembly

      Range
      8044732..8048702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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