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    Itm2c integral membrane protein 2C [ Mus musculus (house mouse) ]

    Gene ID: 64294, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Itm2cprovided by MGI
    Official Full Name
    integral membrane protein 2Cprovided by MGI
    Primary source
    MGI:MGI:1927594
    See related
    Ensembl:ENSMUSG00000026223 AllianceGenome:MGI:1927594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E25; BRI3; E25C; ITM3; Bricd2c; 3110038L02Rik
    Summary
    Enables ATP binding activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Located in lysosome. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human ITM2C (integral membrane protein 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 251.4), cortex adult (RPKM 160.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itm2c in Genome Data Viewer
    Location:
    1 C5; 1 43.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (85822231..85836419)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (85894510..85908698)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01553 Neighboring gene microRNA 8096 Neighboring gene RIKEN cDNA 9930111H07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:87690750-87690933 Neighboring gene calcium binding protein 39 Neighboring gene STARR-positive B cell enhancer ABC_E3285 Neighboring gene STARR-seq mESC enhancer starr_01556 Neighboring gene RIKEN cDNA 4933407L21 gene Neighboring gene predicted gene, 32302 Neighboring gene predicted gene, 51745

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a type II integral transmembrane protein gene, Itm2c, that is highly expressed in the mouse brain. Choi SC, et al. Mol Cells, 2001 Dec 31. PMID 11804340
    2. Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family. Vidal R, et al. Gene, 2001 Mar 21. PMID 11290423
    3. Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues. Rengaraj D, et al. Endocrine, 2007 Apr. PMID 17873332
    4. Mining the Plasma Cell Transcriptome for Novel Cell Surface Proteins. Trezise S, et al. Int J Mol Sci, 2018 Jul 24. PMID 30042348, Free PMC Article
    5. bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death. Wu H, et al. Biochem Biophys Res Commun, 2003 Nov 14. PMID 14592447

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both Itm2a and Itm2c were not detected in the epididymis and vas deferens during sexual maturation.
      Title: Expression and regulation of type II integral membrane protein family members in mouse male reproductive tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of amyloid precursor protein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integral membrane protein 2C
    Names
    integral membrane protein 3
    transmembrane protein BRI3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022417.3 → NP_071862.2  integral membrane protein 2C

      See identical proteins and their annotated locations for NP_071862.2

      Status: VALIDATED

      Source sequence(s)
      AK036377, BE991371, BY255015
      Consensus CDS
      CCDS35641.1
      UniProtKB/Swiss-Prot
      Q91VK4, Q9JI06, Q9JME8
      UniProtKB/TrEMBL
      Q3U0F3
      Related
      ENSMUSP00000027425.10, ENSMUST00000027425.16
      Conserved Domains (1) summary
      smart01039
      Location:138 → 230
      BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      85822231..85836419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VK4.2 GenPept UniProtKB/Swiss-Prot:Q91VK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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