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    Dnah2 dynein, axonemal, heavy chain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303242, updated on 14-Nov-2024

    Summary

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    Symbol
    Dnah2provided by RGD
    Full Name
    dynein, axonemal, heavy chain 2provided by RGD
    Primary source
    RGD:1565087
    See related
    EnsemblRapid:ENSRNOG00000052688 AllianceGenome:RGD:1565087
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DLP2; axo f; Dnahc2
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in cilium movement; cilium-dependent cell motility; and inner dynein arm assembly. Predicted to be located in axoneme and sperm flagellum. Predicted to be part of inner dynein arm. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 78.6), Lung (RPKM 22.7) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnah2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    89
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54641450..54766502, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54142648..54268901, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56029022..56154602, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 38, NatC auxiliary subunit Neighboring gene transmembrane protein 88 Neighboring gene lysine demethylase 6B Neighboring gene uncharacterized LOC102557224 Neighboring gene ephrin B3 Neighboring gene WD repeat containing, antisense to TP53

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of seven rat axonemal dynein heavy chain genes: expression during ciliated cell differentiation. Andrews KL, et al. Mol Biol Cell, 1996 Jan. PMID 8741840, Free PMC Article
    2. Rat hd mutation reveals an essential role of centrobin in spermatid head shaping and assembly of the head-tail coupling apparatus. Liska F, et al. Biol Reprod, 2009 Dec. PMID 19710508, Free PMC Article
    3. Left-right asymmetry and kinesin superfamily protein KIF3A: new insights in determination of laterality and mesoderm induction by kif3A-/- mice analysis. Takeda S, et al. J Cell Biol, 1999 May 17. PMID 10330409, Free PMC Article
    4. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
    5. Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia. Whitfield M, et al. Am J Hum Genet, 2019 Jul 3. PMID 31178125, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of axonemal dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of inner dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 2
    Names
    axonemal dynein heavy chain
    dynein heavy chain 2, axonemal
    dynein heavy chain 2, axonemal-like
    dynein-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100676.1 → NP_001094146.1  dynein axonemal heavy chain 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JYL5
      Related
      ENSRNOP00000070702.1, ENSRNOT00000090809.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      54641450..54766502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767900.4 → XP_008766122.1  dynein axonemal heavy chain 2 isoform X1

      See identical proteins and their annotated locations for XP_008766122.1

      UniProtKB/TrEMBL
      Q2KML4
      Conserved Domains (6) summary
      pfam03028
      Location:3455 → 4146
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:3 → 456
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:954 → 1359
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2737 → 3069
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3097 → 3313
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1496 → 1726
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_039087610.2 → XP_038943538.1  dynein axonemal heavy chain 2 isoform X2

      UniProtKB/TrEMBL
      Q2KML4
      Conserved Domains (4) summary
      COG5245
      Location:930 → 3751
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam08385
      Location:2 → 360
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam12774
      Location:1408 → 1734
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:3766 → 4066
      Dynein_C; Dynein heavy chain C-terminal domain

    3. XM_039087611.2 → XP_038943539.1  dynein axonemal heavy chain 2 isoform X3

      Conserved Domains (3) summary
      COG5245
      Location:92 → 2492
      DYN1; Dynein, heavy chain [Cytoskeleton]
      pfam12774
      Location:149 → 475
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam18199
      Location:2507 → 2807
      Dynein_C; Dynein heavy chain C-terminal domain

    4. XM_039087612.2 → XP_038943540.1  dynein axonemal heavy chain 2 isoform X4

      Conserved Domains (5) summary
      pfam08385
      Location:241 → 798
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1301 → 1709
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12774
      Location:1846 → 2172
      AAA_6; Hydrolytic ATP binding site of dynein motor region D1
      pfam17852
      Location:2334 → 2430
      Dynein_AAA_lid; Dynein heavy chain AAA lid domain
      cl38936
      Location:2162 → 2303
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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