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    Ptrh2 peptidyl-tRNA hydrolase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287593, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ptrh2provided by RGD
    Official Full Name
    peptidyl-tRNA hydrolase 2provided by RGD
    Primary source
    RGD:1306819
    See related
    EnsemblRapid:ENSRNOG00000076410 AllianceGenome:RGD:1306819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306819
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be involved in negative regulation of anoikis; negative regulation of gene expression; and positive regulation of anoikis. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Orthologous to human PTRH2 (peptidyl-tRNA hydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 77.0), Spleen (RPKM 60.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptrh2 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72002450..72012606)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71505113..71515297)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74002151..74012182)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microRNA 21 Neighboring gene vacuole membrane protein 1 Neighboring gene clathrin heavy chain Neighboring gene DEAH-box helicase 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity. De Pereda JM, et al. J Biol Chem, 2004 Feb 27. PMID 14660562
    2. TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells. Brunquell C, et al. Mol Cancer Res, 2012 Nov. PMID 22952044, Free PMC Article
    3. Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. Griffiths GS, et al. J Biol Chem, 2011 Apr 22. PMID 21383007, Free PMC Article
    4. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Jan Y, et al. Cell, 2004 Mar 5. PMID 15006356
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of anoikis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of anoikis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of anoikis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptidyl-tRNA hydrolase 2, mitochondrial
    Names
    Bcl-2 inhibitor of transcription
    NP_001013882.1
    XP_038941489.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013860.2 → NP_001013882.1  peptidyl-tRNA hydrolase 2, mitochondrial

      See identical proteins and their annotated locations for NP_001013882.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      F6S1A7, Q5XI86
      Related
      ENSRNOP00000084315.2, ENSRNOT00000111620.2
      Conserved Domains (1) summary
      cd02430
      Location:67 → 181
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      72002450..72012606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085561.2 → XP_038941489.1  peptidyl-tRNA hydrolase 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      F6S1A7, Q5XI86
      Conserved Domains (1) summary
      cd02430
      Location:67 → 181
      PTH2; Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in ...
    Nucleotide Protein Strain
    Heading Accession and Version

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