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    TPH1 tryptophan hydroxylase 1 [ Balaenoptera acutorostrata (minke whale) ]

    Gene ID: 102997866, updated on 10-Mar-2024

    Summary

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    Gene symbol
    TPH1
    Gene description
    tryptophan hydroxylase 1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Balaenoptera acutorostrata
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti; Balaenopteridae; Balaenoptera
    Orthologs
    human mouse all
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    Genomic context

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    See TPH1 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_06 current mBalAcu1.1 (GCF_949987535.1) 9 NC_080072.1 (39545076..39573099)
    101 previous assembly BalAcu1.0 (GCF_000493695.1) Unplaced Scaffold NW_006726131.1 (6544146..6572163)

    Chromosome 9 - NC_080072.1Genomic Context describing neighboring genes Neighboring gene serum amyloid A-2 protein-like Neighboring gene serum amyloid A like 1 Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene potassium voltage-gated channel subfamily C member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tryptophan 5-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tryptophan 5-hydroxylase 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_949987535.1-RS_2023_06

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mBalAcu1.1

    Genomic

    1. NC_080072.1 Reference mBalAcu1.1

      Range
      39545076..39573099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_007174852.2 → XP_007174914.1  tryptophan 5-hydroxylase 1

      See identical proteins and their annotated locations for XP_007174914.1

      UniProtKB/TrEMBL
      A0A383ZJ79
      Conserved Domains (3) summary
      TIGR01270
      Location:3 → 439
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:18 → 90
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:106 → 435
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    2. XM_007174851.2 → XP_007174913.1  tryptophan 5-hydroxylase 1

      See identical proteins and their annotated locations for XP_007174913.1

      UniProtKB/TrEMBL
      A0A383ZJ79
      Conserved Domains (3) summary
      TIGR01270
      Location:3 → 439
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:18 → 90
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:106 → 435
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
    Nucleotide Protein
    Heading Accession and Version

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