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    Zfp865 zinc finger protein 865 [ Mus musculus (house mouse) ]

    Gene ID: 319748, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Zfp865provided by MGI
    Official Full Name
    zinc finger protein 865provided by MGI
    Primary source
    MGI:MGI:2442656
    See related
    Ensembl:ENSMUSG00000074405 AllianceGenome:MGI:2442656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf865; 6430526N21Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF865 (zinc finger protein 865). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.9), adrenal adult (RPKM 25.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp865 in Genome Data Viewer
    Location:
    7 A1; 7 2.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (5023375..5036225)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (5020376..5033226)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene Flt3 interacting zinc finger protein 1 Neighboring gene STARR-seq mESC enhancer starr_17950 Neighboring gene zinc finger protein 524 Neighboring gene STARR-positive B cell enhancer ABC_E4889 Neighboring gene STARR-positive B cell enhancer ABC_E3696 Neighboring gene zinc finger protein 784 Neighboring gene zinc finger protein 580 Neighboring gene STARR-positive B cell enhancer ABC_E4890 Neighboring gene predicted gene 15510

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model. Liu C, et al. Mol Neurobiol, 2024 Jun. PMID 37989982, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model.
      Title: MiR-184 Mediated the Expression of ZNF865 in Exosome to Promote Procession in the PD Model.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 865

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033383.2 → NP_001028555.1  zinc finger protein 865 isoform 1

      See identical proteins and their annotated locations for NP_001028555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK154737
      Consensus CDS
      CCDS20753.1
      UniProtKB/Swiss-Prot
      D3Z3M5, Q3U3I9
      Related
      ENSMUSP00000075601.5, ENSMUST00000076251.7
      Conserved Domains (6) summary
      PHA03247
      Location:272 → 343
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:163 → 349
      PHA03378; EBNA-3B; Provisional
      COG5048
      Location:349 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:548 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:561 → 584
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001290426.1 → NP_001277355.1  zinc finger protein 865 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC157563, AK051004, BY205386
      Consensus CDS
      CCDS71884.1
      UniProtKB/TrEMBL
      H9KUY5
      Related
      ENSMUSP00000082550.4, ENSMUST00000085427.6
      Conserved Domains (6) summary
      COG5048
      Location:349 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:548 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:666 → 686
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:220 → 242
      zf-C2H2; Zinc finger, C2H2 type
      pfam12446
      Location:272 → 348
      DUF3682; Protein of unknown function (DUF3682)
      pfam13465
      Location:561 → 583
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      5023375..5036225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540059.3 → XP_006540122.1  zinc finger protein 865 isoform X2

      See identical proteins and their annotated locations for XP_006540122.1

      UniProtKB/Swiss-Prot
      D3Z3M5, Q3U3I9
      Conserved Domains (6) summary
      PHA03247
      Location:272 → 343
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:163 → 349
      PHA03378; EBNA-3B; Provisional
      COG5048
      Location:349 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:548 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:561 → 584
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017322300.3 → XP_017177789.1  zinc finger protein 865 isoform X3

      Conserved Domains (7) summary
      PHA03247
      Location:334 → 405
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:225 → 411
      PHA03378; EBNA-3B; Provisional
      COG5048
      Location:411 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:632 → 683
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:610 → 630
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:728 → 748
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:623 → 646
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017322299.1 → XP_017177788.1  zinc finger protein 865 isoform X1

      Conserved Domains (6) summary
      PHA03247
      Location:334 → 405
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:225 → 411
      PHA03378; EBNA-3B; Provisional
      COG5048
      Location:411 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:610 → 630
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:503 → 523
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:623 → 646
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006540060.1 → XP_006540123.1  zinc finger protein 865 isoform X2

      See identical proteins and their annotated locations for XP_006540123.1

      UniProtKB/Swiss-Prot
      D3Z3M5, Q3U3I9
      Conserved Domains (6) summary
      PHA03247
      Location:272 → 343
      PHA03247; large tegument protein UL36; Provisional
      PHA03378
      Location:163 → 349
      PHA03378; EBNA-3B; Provisional
      COG5048
      Location:349 → 421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:548 → 568
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:441 → 461
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:561 → 584
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U3I9.1 GenPept UniProtKB/Swiss-Prot:Q3U3I9

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