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    ECT2 epithelial cell transforming 2 [ Bubalus bubalis (water buffalo) ]

    Gene ID: 102414893, updated on 10-Mar-2024

    Summary

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    Gene symbol
    ECT2
    Gene description
    epithelial cell transforming 2
    See related
    EnsemblRapid:ENSBALG00030036588
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bubalus bubalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bubalus
    Orthologs
    human mouse all
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    Genomic context

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    See ECT2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    103 current NDDB_SH_1 (GCF_019923935.1) 1 NC_059157.1 (139873689..139932116, complement)
    102 previous assembly NDDB_DH_1 (GCF_019923925.1) 1 NC_058343.1 (138641310..138699733, complement)

    Chromosome 1 - NC_059157.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 16 Neighboring gene uncharacterized LOC123334409 Neighboring gene neutral cholesterol ester hydrolase 1 Neighboring gene TNF superfamily member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytokinesis, actomyosin contractile ring assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein ECT2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Bubalus bubalis Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NDDB_SH_1 Primary Assembly

    Genomic

    1. NC_059157.1 Reference NDDB_SH_1 Primary Assembly

      Range
      139873689..139932116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006077755.3 → XP_006077817.1  protein ECT2 isoform X4

      See identical proteins and their annotated locations for XP_006077817.1

      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266 → 341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179 → 242
      PTCB-BRCT; twin BRCT domain

    2. XM_006077754.3 → XP_006077816.1  protein ECT2 isoform X4

      See identical proteins and their annotated locations for XP_006077816.1

      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266 → 341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179 → 242
      PTCB-BRCT; twin BRCT domain

    3. XM_006077753.3 → XP_006077815.1  protein ECT2 isoform X4

      See identical proteins and their annotated locations for XP_006077815.1

      Related
      ENSBALP00030067597.1, ENSBALT00030101427.1
      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266 → 341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179 → 242
      PTCB-BRCT; twin BRCT domain

    4. XM_025288210.2 → XP_025143995.1  protein ECT2 isoform X4

      Conserved Domains (4) summary
      smart00325
      Location:456 → 640
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:631 → 804
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      pfam00533
      Location:266 → 341
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam12738
      Location:179 → 242
      PTCB-BRCT; twin BRCT domain

    5. XM_044944677.1 → XP_044800612.1  protein ECT2 isoform X6

      Conserved Domains (4) summary
      smart00325
      Location:454 → 638
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:629 → 802
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:268 → 347
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:174 → 249
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    6. XM_044944659.1 → XP_044800594.1  protein ECT2 isoform X2

      Conserved Domains (4) summary
      smart00325
      Location:485 → 669
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:660 → 833
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:299 → 378
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:205 → 280
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    7. XM_044944681.1 → XP_044800616.1  protein ECT2 isoform X7

      Conserved Domains (4) summary
      smart00325
      Location:426 → 610
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:601 → 774
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:269 → 348
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:175 → 250
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    8. XM_044944676.1 → XP_044800611.1  protein ECT2 isoform X5

      Conserved Domains (4) summary
      smart00325
      Location:455 → 639
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:630 → 803
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:269 → 348
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:175 → 250
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    9. XM_044944663.1 → XP_044800598.1  protein ECT2 isoform X3

      Conserved Domains (4) summary
      smart00325
      Location:457 → 641
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:632 → 805
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:300 → 379
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:206 → 281
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

    10. XM_044944655.1 → XP_044800590.1  protein ECT2 isoform X1

      Related
      ENSBALP00030067606.1, ENSBALT00030101441.1
      Conserved Domains (4) summary
      smart00325
      Location:486 → 670
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01229
      Location:661 → 834
      PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain
      cd17732
      Location:300 → 379
      BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
      cd17733
      Location:206 → 281
      BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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