Gsta5 glutathione S-transferase alpha 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gsta5provided by RGD
Official Full Name: glutathione S-transferase alpha 5provided by RGD
Primary source: RGD:1593189
See related: EnsemblRapid:ENSRNOG00000029861 AllianceGenome:RGD:1593189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gsta2
Summary: Enables glutathione binding activity and glutathione transferase activity. Involved in xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 6559.5), Kidney (RPKM 3991.1) and 1 other tissue See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 8q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (87985768..87997766)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (79105561..79117472)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (85553659..85564914)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D9Rat30 (e-PCR)
- UniSTS:119169

RH143684 (e-PCR)
- UniSTS:232930

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione binding	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to stilbenoid	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: glutathione S-transferase alpha-2

Names: GHS transferase; GST 1b-1b; GST A2-2; GST Ya2; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-2; glutathione transferase YA subunit

NP_001010921.1

EC 2.5.1.18

XP_017451300.1

EC 2.5.1.18

XP_017451301.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001010921.2 → NP_001010921.1 glutathione S-transferase alpha-2

See identical proteins and their annotated locations for NP_001010921.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P04903, Q63715

UniProtKB/TrEMBL

A0A096MIU0, Q4FZZ3

Related

ENSRNOP00000043510.5, ENSRNOT00000044944.7

Conserved Domains (3) summary

PTZ00057
Location:1 → 208

PTZ00057; glutathione s-transferase; Provisional

cd03208
Location:86 → 220

GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

cd03077
Location:4 → 82

GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

87985768..87997766

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017595811.3 → XP_017451300.1 glutathione S-transferase alpha-2 isoform X1

UniProtKB/Swiss-Prot

P04903, Q63715

UniProtKB/TrEMBL

A0A096MIU0, Q4FZZ3

Related

ENSRNOP00000091487.2, ENSRNOT00000106378.2

Conserved Domains (3) summary

PTZ00057
Location:1 → 208

PTZ00057; glutathione s-transferase; Provisional

cd03208
Location:86 → 220

GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

cd03077
Location:4 → 82

GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
XM_017595812.3 → XP_017451301.1 glutathione S-transferase alpha-2 isoform X1

UniProtKB/Swiss-Prot

P04903, Q63715

UniProtKB/TrEMBL

A0A096MIU0, Q4FZZ3

Conserved Domains (3) summary

PTZ00057
Location:1 → 208

PTZ00057; glutathione s-transferase; Provisional

cd03208
Location:86 → 220

GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases

cd03077
Location:4 → 82

GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...