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    NMRK1 nicotinamide riboside kinase 1 [ Homo sapiens (human) ]

    Gene ID: 54981, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NMRK1provided by HGNC
    Official Full Name
    nicotinamide riboside kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:26057
    See related
    Ensembl:ENSG00000106733 MIM:608704; AllianceGenome:HGNC:26057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NRK1; C9orf95; bA235O14.2
    Summary
    Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NMRK1 in Genome Data Viewer
    Location:
    9q21.13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (75060577..75088155, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (87217117..87244685, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (77675493..77703071, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28468 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19952 Neighboring gene CARNMT1 antisense RNA 1 Neighboring gene chromosome 9 open reading frame 40 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:77579717-77580289 Neighboring gene carnosine N-methyltransferase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19955 Neighboring gene osteoclast stimulating factor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:77751669-77752168 Neighboring gene uncharacterized LOC105376090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of human nicotinamide riboside kinase. Khan JA, et al. Structure, 2007 Aug. PMID 17698003
    2. NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Ratajczak J, et al. Nat Commun, 2016 Oct 11. PMID 27725675, Free PMC Article
    3. Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Bieganowski P, et al. Cell, 2004 May 14. PMID 15137942
    4. Nicotinamide riboside kinase structures reveal new pathways to NAD+. Tempel W, et al. PLoS Biol, 2007 Oct 2. PMID 17914902, Free PMC Article
    5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. nicotinamide riboside kinase 1 (NRK1) is necessary and rate-limiting for the use of exogenous nicotinamide riboside and nicotinamide mononucleotide for NAD(+) synthesis.
      Title: NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.
    2. Crystal structure of NRK1 is reported.
      Title: Crystal structure of human nicotinamide riboside kinase.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20559

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate riboside kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosylnicotinamide kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables ribosylnicotinamide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosylnicotinate kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide riboside kinase 1
    Names
    NRK 1
    RNK 1
    nicotinic acid riboside kinase 1
    nmR-K 1
    ribosylnicotinamide kinase 1
    ribosylnicotinic acid kinase 1
    NP_001121075.1
    NP_001317607.1
    NP_001317608.1
    NP_060351.1
    XP_006717226.1
    XP_011517119.1
    XP_016870357.1
    XP_016870359.1
    XP_016870363.1
    XP_047279503.1
    XP_047279504.1
    XP_047279505.1
    XP_047279506.1
    XP_054219165.1
    XP_054219166.1
    XP_054219167.1
    XP_054219168.1
    XP_054219169.1
    XP_054219170.1
    XP_054219171.1
    XP_054219172.1
    XP_054219173.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127603.2 → NP_001121075.1  nicotinamide riboside kinase 1 isoform 2

      See identical proteins and their annotated locations for NP_001121075.1

      Status: VALIDATED

      Source sequence(s)
      AL133548, BC036804
      Consensus CDS
      CCDS47981.1
      UniProtKB/TrEMBL
      B3KUG3
      Related
      ENSP00000366004.4, ENST00000376808.8
      Conserved Domains (1) summary
      cd02024
      Location:5 → 136
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    2. NM_001330678.2 → NP_001317607.1  nicotinamide riboside kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA412267, AK097144, AL133548, BC036804, CA440629
      Consensus CDS
      CCDS83374.1
      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Related
      ENSP00000366007.1, ENST00000376811.5
      Conserved Domains (1) summary
      cd02024
      Location:12 → 164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    3. NM_001330679.2 → NP_001317608.1  nicotinamide riboside kinase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AA412267, AK097144, AL133548, AL555401, BE502779, CA440629
      Consensus CDS
      CCDS83374.1
      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Conserved Domains (1) summary
      cd02024
      Location:12 → 164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    4. NM_017881.3 → NP_060351.1  nicotinamide riboside kinase 1 isoform 1

      See identical proteins and their annotated locations for NP_060351.1

      Status: VALIDATED

      Source sequence(s)
      AK000566, AL133548, BC036804
      Consensus CDS
      CCDS6650.1
      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
      Related
      ENSP00000354387.4, ENST00000361092.9
      Conserved Domains (1) summary
      cd02024
      Location:5 → 160
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      75060577..75088155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017014874.2 → XP_016870363.1  nicotinamide riboside kinase 1 isoform X4

      UniProtKB/TrEMBL
      B3KUG3
      Conserved Domains (1) summary
      cd02024
      Location:5 → 136
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    2. XM_006717163.3 → XP_006717226.1  nicotinamide riboside kinase 1 isoform X2

      See identical proteins and their annotated locations for XP_006717226.1

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
      Conserved Domains (1) summary
      cd02024
      Location:5 → 160
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    3. XM_047423548.1 → XP_047279504.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q5W125

    4. XM_017014868.2 → XP_016870357.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Conserved Domains (1) summary
      cd02024
      Location:12 → 164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    5. XM_047423549.1 → XP_047279505.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6

    6. XM_017014870.3 → XP_016870359.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6
      UniProtKB/TrEMBL
      B3KUG3
      Conserved Domains (1) summary
      cd02024
      Location:5 → 160
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    7. XM_047423547.1 → XP_047279503.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q5W125

    8. XM_011518817.2 → XP_011517119.1  nicotinamide riboside kinase 1 isoform X1

      See identical proteins and their annotated locations for XP_011517119.1

      UniProtKB/TrEMBL
      B3KUG3, Q5W125
      Conserved Domains (1) summary
      cd02024
      Location:12 → 164
      NRK1; Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR ...

    9. XM_047423550.1 → XP_047279506.1  nicotinamide riboside kinase 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      87217117..87244685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363198.1 → XP_054219173.1  nicotinamide riboside kinase 1 isoform X4

    2. XM_054363194.1 → XP_054219169.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6

    3. XM_054363193.1 → XP_054219168.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q5W125

    4. XM_054363192.1 → XP_054219167.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q5W125

    5. XM_054363196.1 → XP_054219171.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6

    6. XM_054363195.1 → XP_054219170.1  nicotinamide riboside kinase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5W124, Q8N430, Q9NWW6

    7. XM_054363191.1 → XP_054219166.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q5W125

    8. XM_054363190.1 → XP_054219165.1  nicotinamide riboside kinase 1 isoform X1

      UniProtKB/TrEMBL
      Q5W125

    9. XM_054363197.1 → XP_054219172.1  nicotinamide riboside kinase 1 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_023352.1: Suppressed sequence

      Description
      NR_023352.1: This RefSeq was removed because it is now thought that this transcript encodes a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWW6.1 GenPept UniProtKB/Swiss-Prot:Q9NWW6

    Gene LinkOut

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